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Cat. No.: HY-122124

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CAY10583

CAY10583 is a potent and selective full Leukotriene B4 receptor type 2 (BLT2) agonist. CAY10583 directly promotes keratinocyte migration in vitro and accelerates wound closure in vivo. CAY10583 is a promising pharmaceutical agent for diabetic wounds.

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Purity: 99.9%
CAS No.: 862891-27-8
화학식: C₂₅H₂₅NO₃
분자량:387.47

보관:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

CAY10583 Chemical Structure

CAS No.: 862891-27-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

BLT2

All Leukotriene Receptor Isoforms :

In Vitro

CAY10583 (1 nM-1μM; 24 hours) promotes wound closure via keratinocyte migration. And CAY10583 has no significant effect of on keratinocyte proliferation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CAY10583 (administered topically to full-thickness wounds; 10 μM; 14 days) significantly results in a greater wound closure than the control group. The difference in wound closure between the CAY-treated group and the control group is pronounced over time until day 10. And the difference is approximately 6% at day 4 and reaches almost 20% at day 8. Notably, 100% closure was observed in the CAY-treated group at day 14^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Lewis rats (6-9 weeks of age, 180-220 g)^[1]
Dosage:

10 μM; 14 days
Administration:

Administered topically to full-thickness wounds; 10 μM; 14 days
Result:

Accelerated in vivo wound healing by topical application.

Chemical Information

CAS No. 862891-27-8
Appearance Solid
분자량 387.47
화학식 C₂₅H₂₅NO₃
Color White to off-white
SMILES

O=C(C1=CC=CC=C1C2=CC=C(C=C2)CN(C(CCCC)=O)C3=CC=CC=C3)O
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lin Luo, et al. A synthetic leukotriene B 4 receptor type 2 agonist accelerates the cutaneous wound healing process in diabetic rats by indirect stimulation of fibroblasts and direct stimulation of keratinocytes. J Diabetes Complications. 2017 Jan;31(1):13-20 [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

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CAY10583

High-Throughput Bioactive Compound Library

All Leukotriene Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

CAY10583 Related Classifications

HY-122124 Related Classifications