Cedryl acetate
Based on 1 Customer Validation
Cedryl acetate is an orally active α-glucosidase inhibitor with an IC50 of 94 μM against yeast α-glucosidase. Cedryl acetate reduces high-fat diet-induced body weight gain, visceral fat pad weight, adipocyte hypertrophy, hepatic lipid accumulation, glucose intolerance, insulin resistance and gluconeogenesis. Cedryl acetate can be used in the research of obesity and obesity-related metabolic syndrome.
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- Purity: 99.43%
- CAS No.: 77-54-3
- 화학식: C17H28O2
- 분자량:264.40
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보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
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- References
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Biological Activity
Cedryl acetate (20 mg per flask; 6 days) is biotransformed by Cunninghamella elegans into eight distinct hydroxylated, deacetylated, or oxidized metabolites[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (male, 7 weeks old at study start, acclimatized for 3 weeks prior to treatment, obesity induced by 40% fat high-fat diet)[1]
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Dosage:100 mg/kg
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Administration:dietary supplementation; daily; 19 weeks
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Result:Reduced final body weight to 33.68 g (vs. 46.61 g in HFD-only mice) and body weight gain to 8.93 g (vs. 21.69 g in HFD-only mice).
Significantly decreased total visceral fat pad weight, and reduced mean epididymal adipocyte cross-sectional area to 2035 µm2 (vs. 4275 µm2 in HFD-only mice).
Lowered serum levels of LDL-C to 0.72 mmol/L (vs. 1.49 mmol/L in HFD-only mice), HDL-C to 4.83 mmol/L (vs. 6.57 mmol/L in HFD-only mice), total cholesterol to 4.70 mmol/L (vs. 8.57 mmol/L in HFD-only mice), and ALT to 61.4 U/L (vs. 237.3 U/L in HFD-only mice).
Improved glucose homeostasis: reduced fasting blood glucose, lowered blood glucose levels at 60, 90, and 120 minutes during oral glucose tolerance testing (with reduced AUC), and lowered blood glucose levels at 15, 30, 60, and 90 minutes during insulin tolerance testing (with reduced AUC).
Inhibited hepatic gluconeogenesis: reduced blood glucose levels at 30, 60, 90, and 120 minutes during pyruvate tolerance testing (with reduced AUC), and downregulated hepatic mRNA expression of gluconeogenesis-related genes Pepck and G6Pase.
Reduced liver weight and attenuated hepatic lipid accumulation.
Modulated eWAT gene expression: downregulated mRNA levels of adipogenesis/lipid synthesis genes PPARγ, C/EBPα, FABP4, and FAS; upregulated mRNA levels of thermogenesis-related genes PGC-1α, Cidea, Cytc, COX4, and PRDM16.
Showed no significant differences in gut microbiota α-diversity indexes, β-diversity clustering, or phylum/family-level composition compared to HFD-only mice.
Chemical Information
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CAS No. 77-54-3
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Appearance Solid
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분자량 264.40
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화학식 C17H28O2
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Color White to off-white
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SMILES
CC1(C)[C@]2([H])[C@](C)(OC(C)=O)CC[C@]3(C2)[C@H](C)CC[C@@]13[H]
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
용액&용해도
DMSO : 50 mg/mL (189.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.46 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.46 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (280 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Guo J, et al. Dietary Supplementation of Cedryl Acetate Ameliorates Adiposity and Improves Glucose Homeostasis in High-Fat Diet-Fed Mice. Nutrients. 2023;15(4):980. Published 2023 Feb 16. [Content Brief]
[2]. Sultan S, et al. Fungal transformation of cedryl acetate and α-glucosidase inhibition assay, quantum mechanical calculations and molecular docking studies of its metabolites. Eur J Med Chem. 2013;62:764-770. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7821 mL | 18.9107 mL | 37.8215 mL | 94.5537 mL |
| 5 mM | 0.7564 mL | 3.7821 mL | 7.5643 mL | 18.9107 mL | |
| 10 mM | 0.3782 mL | 1.8911 mL | 3.7821 mL | 9.4554 mL | |
| 15 mM | 0.2521 mL | 1.2607 mL | 2.5214 mL | 6.3036 mL | |
| 20 mM | 0.1891 mL | 0.9455 mL | 1.8911 mL | 4.7277 mL | |
| 25 mM | 0.1513 mL | 0.7564 mL | 1.5129 mL | 3.7821 mL | |
| 30 mM | 0.1261 mL | 0.6304 mL | 1.2607 mL | 3.1518 mL | |
| 40 mM | 0.0946 mL | 0.4728 mL | 0.9455 mL | 2.3638 mL | |
| 50 mM | 0.0756 mL | 0.3782 mL | 0.7564 mL | 1.8911 mL | |
| 60 mM | 0.0630 mL | 0.3152 mL | 0.6304 mL | 1.5759 mL | |
| 80 mM | 0.0473 mL | 0.2364 mL | 0.4728 mL | 1.1819 mL | |
| 100 mM | 0.0378 mL | 0.1891 mL | 0.3782 mL | 0.9455 mL |
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