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United States

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Cat. No.: HY-117559

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CGP-75355

CGP-75355 is an inhibitor of HIV-1 protease with IC₅₀ of 26 nM. CGP-75355 is a bis(L-tert-leucine) derivative.

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CAS No.: 191594-64-6
화학식: C₃₉H₅₃N₅O₇
분자량:703.87

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

CGP-75355 Chemical Structure

CAS No.: 191594-64-6

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
Protocol (1)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

CGP-75355 is an inhibitor of HIV-1 protease with IC₅₀ of 26 nM. CGP-75355 is a bis(L-tert-leucine) derivative^[1]^[2].

All HIV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MT2	ED₅₀	0.7 nM Compound: 25a	Concentration required to inhibit 50% of RT production in HIV-1/MN-infected MT-2 cells. Concentration required to inhibit 50% of RT production in HIV-1/MN-infected MT-2 cells.	[PMID: 9719591]
MT2	IC₅₀	58 nM Compound: 25a	The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells. The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.	[PMID: 9719591]

Chemical Information

CAS No. 191594-64-6
분자량 703.87
화학식 C₃₉H₅₃N₅O₇
SMILES

CC(C)(C)[C@@H](C(N[C@@H](CC1=CC=CC=C1)[C@@H](O)CN(NC([C@H](C(C)(C)C)NC(OC)=O)=O)CC2=CC=C(C3=CC=CC=C3)C=C2)=O)NC(OC)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocol

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bold, G., et al., (1998). New aza-dipeptide analogues as potent and orally absorbed HIV-1 protease inhibitors: candidates for clinical development. Journal of medicinal chemistry, 41(18), 3387-3401. [Content Brief]

[2]. Wieslaw M. Kazmierski, (2011). Antiviral Drugs: From Basic Discovery Through Clinical Trials.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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