Chitobiose
Chitobiose is an orally active chitosan oligosaccharide (degree of polymerization 2). Chitobiose shows hepatoprotective activity and counteracts CCl4-induced elevation of plasma aspartate transaminase and alanine transaminase activities in rats. Chitobiose can be used for the research of carbon tetrachloride-induced acute hepatotoxicity.
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- CAS No.: 577-76-4
- 화학식: C12H24N2O9
- 분자량:340.33
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Chitobiose (100 μM; 24 h prior to LPS stimulation) exhibits no anti-inflammatory activity in LPS (HY-D1056)-stimulated RAW264.7 cells, as it does not alter levels of IL-1β, IL-10, IL-17A, or IFN-γ[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7 macrophage cells
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Concentration:100 μM
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Incubation Time:24 h (prior to 6 h LPS stimulation)
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Result:Showed no significant effect on the levels of IL-1β, IL-10, IL-17A, and IFN-γ compared to the control group (p > 0.05).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CCl4-induced acute hepatotoxicity Wistar (male, 7 weeks old, 165-185 g)[2]
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Dosage:300 mg/kg
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Administration:p.o.; twice (30 minutes before and 3 hours after CCl4 exposure)
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Result:Significantly suppressed the CCl4-induced increase in the sum of malondialdehyde and 4-hydroxy-2-alkenals in both plasma and liver at 24 hours post-CCl4 treatment.
Significantly reduced the elevated plasma aspartate transaminase (AST) and alanine transaminase (ALT) activities at both 6 hours and 24 hours post-CCl4 treatment.
Chemical Information
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CAS No. 577-76-4
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분자량 340.33
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화학식 C12H24N2O9
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SMILES
N[C@H]([C@H]([C@@H]([C@@H](CO)O)O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1N)O)O)CO)O)C=O
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Zhao Q, et al. Chitoheptaose Promotes Heart Rehabilitation in a Rat Myocarditis Model by Improving Antioxidant, Anti-Inflammatory, and Antiapoptotic Properties. Oxid Med Cell Longev. 2020;2020:2394704. Published 2020 Apr 11. [Content Brief]
[2]. Chen AS, et al. Effect of chitobiose and chitotriose on carbon tetrachloride-induced acute hepatotoxicity in rats. Biol Pharm Bull. 2005;28(10):1971-1973. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Chitobiose Related Classifications
HY-N7697F Related Classifications
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