Chloropyramine
Chloropyramine is competitive reversible H1 receptor antagonist. Chloropyramine also has anti-tumour activity in breast cancer. Chloropyramine can be used for the research of allergic conditions, such as conjunctivitis and bronchial asthma.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 59-32-5
- 화학식: C16H20ClN3
- 분자량:289.80
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocol
- 순도&문서
- References
-
Help & FAQs
All Histamine Receptor Isoforms
More
Biological Activity
제품 설명
IC50 & Target
[1]|
H1 Receptor |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MCF-10A | IC50 |
>60 μM
Compound: 1
|
Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
|
[PMID: 35569251] |
| MDA-MB-157 | IC50 |
43.06 μM
Compound: 1
|
Antiproliferative activity against human MDA-MB-157 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-157 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
|
[PMID: 35569251] |
| MDA-MB-231 | IC50 |
49.73 μM
Compound: 1
|
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
|
[PMID: 35569251] |
| MDA-MB-453 | IC50 |
>60 μM
Compound: 1
|
Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
|
[PMID: 35569251] |
In Vitro
Chloropyramine (25, 50 μM; 24 h, 48 h) induces SASH1 expression and apoptosis in breast cancer cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Breast cancer cell lines
-
Concentration:25 or 50 μM
-
Incubation Time:24 h
-
Result:Increased SASH1 expression in breast cancer cell lines.
-
Cell Line:T47D, MDA-MB-231 and BT-54 cells
-
Concentration:50 μM
-
Incubation Time:48 h
-
Result:Induced apoptosis in breast cancer cell lines.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Rats[2]
-
Dosage:10 mg/kg
-
Administration:Intraperitoneal
-
Result:Reduced histamine-induced hypothermia.
Chemical Information
-
CAS No. 59-32-5
-
분자량 289.80
-
화학식 C16H20ClN3
-
SMILES
CN(CCN(C1=CC=CC=N1)CC2=CC=C(Cl)C=C2)C
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Chloropyramine Related Classifications
HY-119995 Related Classifications
Powered by Bioz