Choline theophyllinate
Based on 4 publication(s) in Google Scholar
Choline theophyllinate (Oxtriphylline) is a choline salt of theophylline with anti-asthmatic activity.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.95%
- CAS No.: 4499-40-5
- 화학식: C12H21N5O3
- 분자량:283.33
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보관:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Publications Citing Use of MedChemExpress (MCE) Choline theophyllinate
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Biological Activity
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Human Endogenous Metabolite |
Chemical Information
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CAS No. 4499-40-5
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Appearance Solid
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분자량 283.33
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화학식 C12H21N5O3
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Color White to off-white
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SMILES
C[N+](C)(CCO)C.CN1C2=C(C(N(C1=O)C)=O)N=C[N-]2
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Synonyms
Oxtriphylline
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (4)
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Journal Impact Factor
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Most Recent
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Cell Death Dis
DHRS2 inhibits cell growth and metastasis in ovarian cancer by downregulation of CHKα to disrupt choline metabolism. [Abstract]2022 Oct 3;13(10):845. PMID: 36192391 -
Phytomedicine
Motherwort synergized with oxytocin for postpartum hemorrhage prevention: Integrated clinical efficacy and mechanism exploration. [Abstract]2025 Sep:145:156951. PMID: 40527062 -
J Hazard Mater
EHDPP impairs intestinal microbiota homeostasis and induces placental injury through choline mediated gut-placenta axis. [Abstract]2025 Jun 5:489:137573. PMID: 40007358
Choline theophyllinate purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2025 Jun 5:489:137573. [Abstract]
Choline (30 μM, 24 h) demonstrated no cytotoxic effects but partially mitigated the inhibition of cell viability induced by EHDPP in HTR-8/SVneo and JEG-3 cells.
Choline theophyllinate purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2025 Jun 5:489:137573. [Abstract]
Choline (30 μM, 24 h) reversed EHDPP-induced cell migration inhibition in HTR-8/SVneo cells.
Choline theophyllinate purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2025 Jun 5:489:137573. [Abstract]
Choline (30 μM, 24 h) reversed the EHDPP-induced decrease of mRNA levels of TNF-α, IL-6, and IL-1β in HTR-8/SVneo cells.
Choline theophyllinate purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2025 Jun 5:489:137573. [Abstract]
Choline supplementation (25 mM choline-containing water for 31.5 days) significantly increased uterine size, fetal weight, placental weight, and placental diameter that were reduced by EHDPP exposure.
Choline theophyllinate purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2025 Jun 5:489:137573. [Abstract]
Choline supplementation (25 mM choline-containing water for 31.5 days) alleviated the decrease in mRNA expression of the proliferation marker Ki67 and the vascular differentiation marker CD31 induced by EHDPP.
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Antioxidants (Basel)
Role of Mitochondrial Reactive Oxygen Species-Mediated Chaperone-Mediated Autophagy and Lipophagy in Baicalin and N-Acetylcysteine Mitigation of Cadmium-Induced Lipid Accumulation in Liver. [Abstract]2024 Jan 17;13(1):115. PMID: 38247538
용액&용해도
H2O : 250 mg/mL (882.36 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Data Sheet (274 KB)
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References
[1]. Brumlik J, Theophylline compounds and myasthenia gravis. II. Clinical report of nine cases. Clin Pharmacol Ther. 1973 May-Jun;14(3):380-5. [Content Brief]
[2]. Chan KW, A comparative study of the use of choline theophyllinate and a sustained-release theophylline in adults with chronic asthma. Ann Acad Med Singapore. 1985 Jul;14(3):470-4. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.5295 mL | 17.6473 mL | 35.2945 mL | 88.2363 mL |
| 5 mM | 0.7059 mL | 3.5295 mL | 7.0589 mL | 17.6473 mL | |
| 10 mM | 0.3529 mL | 1.7647 mL | 3.5295 mL | 8.8236 mL | |
| 15 mM | 0.2353 mL | 1.1765 mL | 2.3530 mL | 5.8824 mL | |
| 20 mM | 0.1765 mL | 0.8824 mL | 1.7647 mL | 4.4118 mL | |
| 25 mM | 0.1412 mL | 0.7059 mL | 1.4118 mL | 3.5295 mL | |
| 30 mM | 0.1176 mL | 0.5882 mL | 1.1765 mL | 2.9412 mL | |
| 40 mM | 0.0882 mL | 0.4412 mL | 0.8824 mL | 2.2059 mL | |
| 50 mM | 0.0706 mL | 0.3529 mL | 0.7059 mL | 1.7647 mL | |
| 60 mM | 0.0588 mL | 0.2941 mL | 0.5882 mL | 1.4706 mL | |
| 80 mM | 0.0441 mL | 0.2206 mL | 0.4412 mL | 1.1030 mL | |
| 100 mM | 0.0353 mL | 0.1765 mL | 0.3529 mL | 0.8824 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Choline theophyllinate Related Classifications
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