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Cat. No.: HY-187683

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CN045

CN045 is a blood-brain barrier-permeable, selective M1 muscarinic receptor ligand with an IC₅₀ value of 1 μM. CN045 enhances remyelination in mouse brain regions. CN045 can be used in studies related to multiple sclerosis.

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CAS No.: 401809-27-6
화학식: C₁₆H₂₂Cl₃NO₂
분자량:366.71

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

CN045 Chemical Structure

CAS No.: 401809-27-6

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

mAChR1

1 μM (IC₅₀)

All mAChR Isoforms :

In Vitro

CN045 (5 days) potently promotes differentiation of primary mouse PLP-EGFP transgenic oligodendrocyte progenitor cells in vitro with an EC₅₀ of 40 nM, yielding a higher percentage of mature oligodendrocytes than Clemastine (HY-B0298)^[1].
CN045 (5 days) potently stimulates differentiation of primary mouse OPCs into mature, myelin protein-expressing oligodendrocytes with an EC₅₀ of 0.04 μM^[2].
CN045 (1 μM; 14 days) promotes myelin-like ensheathment of engineered nanofibers by primary mouse OPCs, increasing both oligodendrocyte numbers and ensheathment length^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CN045 (10 mg/kg; i.p.; daily; 6 weeks) significantly enhances remyelination in both white and gray matter regions of Cuprizone (HY-W115718)/Sirolimus (HY-10219)-demyelinated C57/BL/6J mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57/BL/6J (8-week-old male; multiple sclerosis model via 12 weeks of 0.3% cuprizone chow plus daily i.p. sirolimus 10 mg/kg-induced demyelination)^[2]
Dosage:

10 mg/kg
Administration:

i.p.; daily; 6 weeks
Result:

Increased remyelination in the corpus callosum, hippocampus, and cerebral cortex compared to vehicle treatment.
Increased the number of PPD+ myelinated axons per unit area in the corpus callosum.
Increased the percentage area of PLP staining in the hippocampus.
Increased the percentage area of PLP staining in the cerebral cortex.

Chemical Information

CAS No. 401809-27-6
분자량 366.71
화학식 C₁₆H₂₂Cl₃NO₂
SMILES

ClC1=C(OCCOCCN2CCC(C)CC2)C(Cl)=CC(Cl)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Raubenolt B, et al. Structural Basis of M1 Muscarinic and H3 Histamine Receptor Inhibition in OPC Differentiation[J]. bioRxiv, 2026: 2026.04. 01.715893.

[2]. Yang Y, et al. A novel small molecule remyelination therapy for multiple sclerosis. npj drug discovery. 2026 Jul 23;3(1):24.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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