Cyprolidol
Cyprolidol is an orally active inhibitor of acetylcholine receptor and histamine receptor with potential antidepressant activity. Cyprolidol inhibits acetylcholine-induced hypotensive response, histamine-induced systolic blood pressure decrease, tyramine-induced systolic blood pressure increase, serotonin-induced systolic blood pressure response in anesthetized animals, and bretylium-induced systolic blood pressure increase in anesthetized cats. Cyprolidol potentiates norepinephrine-induced systolic blood pressure increase, slightly potentiates epinephrine-induced systolic blood pressure increase, and enhances the anesthetic depth of barbiturates. Cyprolidol can be used in the research of depression.
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- CAS No.: 4904-00-1
- 화학식: C21H19NO
- 분자량:301.38
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Histamine Receptor Isoforms
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Biological Activity
Cyprolidol (10 mg/kg; i.v.; single dose) produces a mean -34.16 mmHg systolic pressure fall in anesthetized dogs, while also potentiating norepinephrine and epinephrine pressor responses and inhibiting tyramine, histamine, acetylcholine, and serotonin responses[1].
Cyprolidol (10-30 mg/kg; i.v.; single dose) produces a biphasic systolic pressure response (-34.00 mmHg fall followed by +38.00 mmHg rise) in anesthetized cats, while also potentiating norepinephrine and epinephrine pressor responses, inhibiting tyramine, histamine, acetylcholine, serotonin, and bretylium responses, and at 30 mg/kg i.v. reversing bretylium-induced pressure rises to falls[1].
Cyprolidol (30 mg/kg; p.o.; daily; 14 days) does not alter normotensive systolic pressure in conscious dogs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 4904-00-1
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분자량 301.38
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화학식 C21H19NO
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SMILES
OC(C1=CC=CC=C1)(C2=CC=CC=C2)[C@H]3[C@H](C4=CC=NC=C4)C3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)