D-Alanine-d3
Based on 1 Customer Validation
D-Alanine-d3 is the deuterium labeled D-Alanine. D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.
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- Purity: 99.83%
- CAS No.: 177614-69-6
- 화학식: C3H4D3NO2
- 분자량:92.11
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 177614-69-6
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Unlabeled Cas 338-69-2
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Appearance Solid
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분자량 92.11
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화학식 C3H4D3NO2
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Color White to off-white
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SMILES
OC([C@H](N)C([2H])([2H])[2H])=O
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Synonyms
(R)-Alanine-d3; Ba 2776-d3; D-α-Alanine-d3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
H2O : 100 mg/mL (1085.66 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Schmieden V, et al. Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds. Mol Pharmacol. 1995 Nov;48(5):919-27. [Content Brief]
[3]. Saitoh T, et al. A novel antagonist, phenylbenzene omega-phosphono-alpha-amino acid, for strychnine-sensitive glycine receptors in the rat spinal cord. Br J Pharmacol. 1994 Sep;113(1):165-70. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 10.8566 mL | 54.2829 mL | 108.5658 mL | 271.4146 mL |
| 5 mM | 2.1713 mL | 10.8566 mL | 21.7132 mL | 54.2829 mL | |
| 10 mM | 1.0857 mL | 5.4283 mL | 10.8566 mL | 27.1415 mL | |
| 15 mM | 0.7238 mL | 3.6189 mL | 7.2377 mL | 18.0943 mL | |
| 20 mM | 0.5428 mL | 2.7141 mL | 5.4283 mL | 13.5707 mL | |
| 25 mM | 0.4343 mL | 2.1713 mL | 4.3426 mL | 10.8566 mL | |
| 30 mM | 0.3619 mL | 1.8094 mL | 3.6189 mL | 9.0472 mL | |
| 40 mM | 0.2714 mL | 1.3571 mL | 2.7141 mL | 6.7854 mL | |
| 50 mM | 0.2171 mL | 1.0857 mL | 2.1713 mL | 5.4283 mL | |
| 60 mM | 0.1809 mL | 0.9047 mL | 1.8094 mL | 4.5236 mL | |
| 80 mM | 0.1357 mL | 0.6785 mL | 1.3571 mL | 3.3927 mL | |
| 100 mM | 0.1086 mL | 0.5428 mL | 1.0857 mL | 2.7141 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
D-Alanine-d3 Related Classifications
HY-41700S Related Classifications
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