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Cat. No.: HY-175890

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DDB1 ligand-2

DDB1 ligand-2 is an E3 ligase ligand. DDB1 ligand-2 can be coupled with BRD4 ligand JQ-1 carboxylic acid (HY-78695) via the linker NH2-C5-NH-Boc (HY-W004710) to form PROTAC MM-02-08 (HY-161167).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₅H₂₁ClN₂O₄
분자량:448.90

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

DDB1 ligand-2 Chemical Structure

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가격

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수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

DDB1 ligand-2 is an E3 ligase ligand. DDB1 ligand-2 can be coupled with BRD4 ligand JQ-1 carboxylic acid (HY-78695) via the linker NH2-C5-NH-Boc (HY-W004710) to form PROTAC MM-02-08 (HY-161167)^[1].

IC₅₀ & Target

DDB1

All Ligands for E3 Ligase Isoforms :

Chemical Information

분자량 448.90
화학식 C₂₅H₂₁ClN₂O₄
SMILES

O=C(O)C1=CC=C(C2CC(C3=CC(OCC4=CC=CC=C4)=CC=C3)=NN2C(CCl)=O)C=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Meyers M, et al. Targeted Protein Degradation through Recruitment of the CUL4A Complex Adaptor Protein DDB1. bioRxiv [Preprint]. 2023 Aug 12:2023.08.11.553046.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

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DDB1 ligand-2

All Ligands for E3 Ligase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

DDB1 ligand-2 Related Classifications

HY-175890 Related Classifications