DJ4
Based on 1 Customer Validation
DJ4 is a ATP-competitive inhibitor of ROCK1/2 (IC50 values:5 and 50 nM) and MRCKα/β (IC50 values:10 and 100 nM). DJ4 blocks stress fiber formation and inhibits migration and invasion of cancer cells. DJ4 can be used for study of lung cancer, breast cancer, and pancreatic (PANC-1) cancer.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.25%
- CAS No.: 1681020-24-5
- 화학식: C19H16N4OS
- 분자량:348.42
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
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ROCK1 5 nM (IC50) |
ROCK2 50 nM (IC50) |
MRCKα 10 nM (IC50) |
MRCKβ 100 nM (IC50) |
DJ4 (2.5-5 µM; 24 h) inhibits migration and invasion of cancer cells[1].
DJ4 (2.5-5 µM; 24 h) blocks recombinant MYPT1 phosphorylation in A549 cells[1].
A549 cells[1]
2.5 µM, 5 µM
24 h
Effectively blocked recombinant MYPT1 phosphorylation.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human lung (H522), breast (MDA-MB-231), and pancreatic (PANC-1) cancer cell lines
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Concentration:2.5 µM, 5 µM
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Incubation Time:24 h
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Result:Significantly inhibited migration of cancer cells.
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Cell Line:A549 cells
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Concentration:2.5 µM, 5 µM
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Incubation Time:24 h
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Result:Effectively blocked recombinant MYPT1 phosphorylation.
Chemical Information
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CAS No. 1681020-24-5
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Appearance Solid
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분자량 348.42
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화학식 C19H16N4OS
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Color Off-white to light yellow
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SMILES
O=C1N/C(S/C1=C/C2=CNC3=C2C=CC=N3)=N\CCC4=CC=CC=C4
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 10 mg/mL (28.70 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8701 mL | 14.3505 mL | 28.7010 mL | 71.7525 mL |
| 5 mM | 0.5740 mL | 2.8701 mL | 5.7402 mL | 14.3505 mL | |
| 10 mM | 0.2870 mL | 1.4350 mL | 2.8701 mL | 7.1752 mL | |
| 15 mM | 0.1913 mL | 0.9567 mL | 1.9134 mL | 4.7835 mL | |
| 20 mM | 0.1435 mL | 0.7175 mL | 1.4350 mL | 3.5876 mL | |
| 25 mM | 0.1148 mL | 0.5740 mL | 1.1480 mL | 2.8701 mL |
DJ4 Related Classifications
HY-125221 Related Classifications
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