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Cat. No.: HY-184332

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DNMT3A-IN-4

DNMT3A-IN-4 is a DNMT3A inhibitor with an IC₅₀ of 33.4 μM against human DNMT3A. DNMT3A-IN-4 inhibits the proliferation of colorectal cancer cells and can be used for the research of colorectal cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₀H₁₅N₅O₃
분자량:373.36

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

DNMT3A-IN-4 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

DNMT3A

33.4 μM (IC₅₀)

All DNA Methyltransferase Isoforms :

In Vitro

DNMT3A-IN-4 (compound 6o) (100-320 μM; 1 h) preferentially inhibits recombinant human DNMT3A/3L over DNMT1, and shows only weak inhibitory activity against DNMT1 even at concentrations as high as 320 μM^[1].
DNMT3A-IN-4 (25-150 μM; 24-72 h) does not reduce the viability of HCT116 colorectal cancer cells^[1].
DNMT3A-IN-4 (100 μM; 24 h) does not reduce the protein abundance of DNMT1 or DNMT3A in HCT116 colorectal cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 373.36
화학식 C₂₀H₁₅N₅O₃
SMILES

O=C1NC2=C(C(C3=CC=C(N4C=CN=C4)C=C3)C5=C(O2)C=C(O)C=C5)C(N)=N1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Chen T, et al. Rational design and synthesis of a heterocycle scaffold for DNMT3A inhibition. Bioorganic chemistry. 2026 Sep 05;179:110025. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
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CAS No.:
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Purity:
수량:

DNMT3A-IN-4

All DNA Methyltransferase Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

DNMT3A-IN-4 Related Classifications

HY-184332 Related Classifications

Bioz

Keywords

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