EFdA-TP tetralithium
Based on 1 publication(s) in Google Scholar
EFdA-TP tetralithium is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP tetralithium inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP tetralithium inhibits HIV-1 RT with multiple mechanisms.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 96.91%
- 화학식: C12H11FLi4N5O12P3
- 분자량:556.93
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보관:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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용액&용해도
- Protocol
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) EFdA-TP tetralithium
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Biological Activity
제품 설명
In Vitro
EFdA-TP (0.05-10 μM; for 15 min) tetralithium inhibits RT-catalyzed DNA synthesis as an ICT or DCT[1].
EFdA-TP tetralithium can block RT as a translocation-defective RT inhibitor that dramatically slows DNA synthesis, acting as a de facto immediate chain terminator[1].
EFdA-TP tetralithium can function as a delayed chain terminator, allowing incorporation of an additional dNTP before blocking DNA synthesis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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분자량 556.93
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화학식 C12H11FLi4N5O12P3
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Color White to off-white
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SMILES
O=[P](O[P](O[P](O[Li])(O[Li])=O)(O[Li])=O)(O[Li])OC[C@]1(O[C@@](C[C@@H]1O)([H])N2C3=NC(F)=NC(N)=C3N=C2)C#C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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bioRxiv
Structural and Mechanistic Basis of F227C-Mediated Hypersusceptibility to Islatravir in HIV-1 Reverse Transcriptase. [Abstract]2026 Jun 10:2026.06.08.730881. PMID: 42327331
용액&용해도
In Vitro:
H2O : ≥ 100 mg/mL (179.56 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.7956 mL | 8.9778 mL | 17.9556 mL | 44.8889 mL |
| 5 mM | 0.3591 mL | 1.7956 mL | 3.5911 mL | 8.9778 mL | |
| 10 mM | 0.1796 mL | 0.8978 mL | 1.7956 mL | 4.4889 mL | |
| 15 mM | 0.1197 mL | 0.5985 mL | 1.1970 mL | 2.9926 mL | |
| 20 mM | 0.0898 mL | 0.4489 mL | 0.8978 mL | 2.2444 mL | |
| 25 mM | 0.0718 mL | 0.3591 mL | 0.7182 mL | 1.7956 mL | |
| 30 mM | 0.0599 mL | 0.2993 mL | 0.5985 mL | 1.4963 mL | |
| 40 mM | 0.0449 mL | 0.2244 mL | 0.4489 mL | 1.1222 mL | |
| 50 mM | 0.0359 mL | 0.1796 mL | 0.3591 mL | 0.8978 mL | |
| 60 mM | 0.0299 mL | 0.1496 mL | 0.2993 mL | 0.7481 mL | |
| 80 mM | 0.0224 mL | 0.1122 mL | 0.2244 mL | 0.5611 mL | |
| 100 mM | 0.0180 mL | 0.0898 mL | 0.1796 mL | 0.4489 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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