ERB-2
ERB-2 is a selective ERβ PROTAC degrader. ERB-2 removes the inhibitory effect of ERβ on ROS, leading to the accumulation of ROS, mitochondrial damage, and ultimately triggering cell apoptosis (apoptosis). ERB-2 significantly inhibits tumor growth in the nude mouse model of NCI-H1975OR tumors. ERB-2 can be used for the study of non-small cell lung cancer.
(Pink: Estrogen Receptor/ERR ligand (HY-180851); Blue: VHL ligand (HY-112078); Black: linker (HY-141209)).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- 화학식: C46H55N5O11S
- 분자량:886.02
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All PROTACs Isoforms
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Biological Activity
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ERβ |
VHL |
Chemical Information
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분자량 886.02
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화학식 C46H55N5O11S
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SMILES
O=C([C@H]1N(C([C@H](C(C)(C)C)NC(COCCOCCOCCOC2=CC(C3=NC4=CC(O)=CC(C=C)=C4O3)=CC=C2O)=O)=O)C[C@H](O)C1)N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ERB-2 Related Classifications
HY-180850 Related Classifications
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