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Cat. No.: HY-122063

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FR260330

FR260330 is a selective, orally active inhibitor for inducible nitric oxide synthase (iNOS) through suppression of iNOS dimerization. FR260330 inhibits the NO accumulation in rat splenocytes and human DLD-110 cells, with IC₅₀ of 27 and 10 nM. FR260330 ameliorates the Lipopolysaccharides (HY-D1056)-induced inflammatory diseases in rats model.

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CAS No.: 442198-67-6
화학식: C₂₉H₂₈ClF₃N₆O₄
분자량:617.02

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

FR260330 Chemical Structure

CAS No.: 442198-67-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

iNOS

All NO Synthase Isoforms :

Chemical Information

CAS No. 442198-67-6
분자량 617.02
화학식 C₂₉H₂₈ClF₃N₆O₄
SMILES

O=C(N1CCC(OC2=NC=NC(C(F)(F)F)=C2)CC1)CNC([C@@H](NC(/C=C/C3=CC=C(Cl)C=C3)=O)CC4=CC=CC=N4)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chida N, et al., Pharmacological profile of FR260330, a novel orally active inducible nitric oxide synthase inhibitor. Eur J Pharmacol. 2005 Feb 10;509(1):71-6. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
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FR260330

All NO Synthase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

FR260330 Related Classifications

HY-122063 Related Classifications