Gartisertib-d8
Gartisertib-d8 (VX-803-d8) is the deuterium labeled Gartisertib (HY-136270). Gartisertib (VX-803) is an ATP-competitive, orally active, and selective ATR inhibitor, with a Ki of <150 pM. Gartisertib potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation with an IC50 of 8 nM. Antitumor activity.
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- CAS No.: 1792214-00-6
- 화학식: C25H21D8F2N9O3
- 분자량:549.60
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
신청
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1792214-00-6
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Unlabeled CAS 1613191-99-3
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분자량 549.60
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화학식 C25H21D8F2N9O3
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SMILES
O=C(C1=C2N=CC(F)=CN2N=C1N)NC3=C(N4CCC(C(N5C([2H])([2H])C([2H])([2H])N(C6COC6)C([2H])([2H])C5([2H])[2H])=O)CC4)C(F)=CN=C3
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Synonyms
VX-803-d8; M4344-d8; ATR inhibitor 2-d8
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Gartisertib-d8 Related Classifications
HY-136270S Related Classifications
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