RBL2 - RB transcriptional corepressor like 2 Gene

Also Known as Rb2; P130; BRUWAG

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5934

About RBL2

Cytogenetic location: 16q12.2 Genomic coordinates (GRCh38): 16:53,434,471-53,491,648 (from NCBI)

This gene has 9 transcripts (splice variants), 211 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 41.9), testis (RPKM 38.9) and 25 other tissues.

Summary

Enables promoter-specific chromatin binding activity. Involved in regulation of lipid kinase activity. Acts upstream of or within negative regulation of gene expression. Located in chromosome; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

RBL2 Products (5)

mRNA	Protein	Name
NM_001323608.2	NP_001310537.1	retinoblastoma-like protein 2 isoform 1
NM_001323609.2	NP_001310538.1	retinoblastoma-like protein 2 isoform 2
NM_001323610.2	NP_001310539.1	retinoblastoma-like protein 2 isoform 3
NM_001323611.1	NP_001310540.1	retinoblastoma-like protein 2 isoform 4
NM_005611.4	NP_005602.3	retinoblastoma-like protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	25100735	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	1331501	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25100735	GOA
involved in regulation of lipid kinase activity	IDA IDA: Inferred from direct assay	16286473	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBL2 Protein Structure

DUF3452

RB_A

RB_B

0
200
400
600
800
1000
1139 a.a.

Protein Preferred Names	Protein Names
retinoblastoma-like protein 2	130 kDa retinoblastoma-associated protein

RBL2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RBL2	Q08999	RBBP8	Homo sapiens	Q99708-2	Y2H Prey Pooling	32296183
Intra	RBL2	Q08999	RBBP8	Homo sapiens	Q99708-2	Validated Y2H	32296183
Intra	RBL2	Q08999	RBBP8	Homo sapiens	Q99708-2	Y2H Array	32296183
Intra	RBL2	Q08999	RBBP8	Homo sapiens	I6L8A6	Y2H	27107012
Intra	RBL2	Q08999	RBBP8	Homo sapiens	I6L8A6	BFG-2H	27107012
Cross	RBL2	Q08999	Pax3	Mus musculus	P24610	Anti Bait CoIP	9464541
Cross	RBL2	Q08999	Pax3	Mus musculus	P24610	Y2H	9464541
Cross	RBL2	Q08999	Vsx2	Mus musculus	Q61412	Y2H	9464541
Cross	RBL2	Q08999	Vsx2	Mus musculus	Q61412	Pull Down	9464541
Intra	RBL2	Q08999	LIN54	Homo sapiens	Q6MZP7	Anti Tag CoIP	17531812
Intra	RBL2	Q08999	LIN54	Homo sapiens	Q6MZP7	Anti Bait CoIP	17531812
Cross	RBL2	Q08999	Sirt1	Mus musculus	Q923E4	Anti Tag CoIP	17620057
Intra	RBL2	Q08999	CDK4	Homo sapiens	P11802	Protein Kinase Assay	22094256
Intra	RBL2	Q08999	E2F4	Homo sapiens	Q16254	Anti Bait CoIP	17531812
Intra	RBL2	Q08999	E2F4	Homo sapiens	Q16254	Anti Tag CoIP	17531812
Intra	RBL2	Q08999	E2F4	Homo sapiens	Q16254	Anti Bait CoIP	22002537
Intra	RBL2	Q08999	PPP2CA	Homo sapiens	P67775	Phosphatase Assay	15467457
Intra	RBL2	Q08999	DGKZ	Homo sapiens	Q13574-2	Pull Down	16286473
Cross	RBL2	Q08999	e1a_ade05	Human adenovirus C	P03255	Pull Down	1331501
Cross	RBL2	Q08999	e1a_ade05	Human adenovirus C	P03255	Affinity Techniques	1331501

Cross: Cross-species interaction Intra: Intraspecies interaction

RBL2 Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P81302	Phospho-Rb2 p130 (Ser952) Antibody (YA1034)	WB, IHC-F, IHC-P, ICC/IF	Human
HY-P81302A	Phospho-Rb2 p130 (Thr986) Antibody (YA1035)	WB, IP	Human
HY-P81302AA	Phospho-Rb2 p130 (Thr986) Antibody (YA1035)(PBS only)	WB, IP	Human

Related Diseases

Diseases	Alias
Brunet-Wagner Neurodevelopmental Syndrome	BRUWAG
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Papilloma	Papillomatosis
Spastic Paraplegia 27, Autosomal Recessive	SPG27 Hereditary Spastic Paraplegia 27 Autosomal Recessive Spastic Paraplegia Type 27 Autosomal Recessive Spastic Paraplegia 27 Spastic Paraplegia-27, Autosomal Recessive
Bilateral Retinoblastoma
Unilateral Retinoblastoma
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Retinal Cancer	Malignant Neoplasm Of Retina Retinal Neoplasms Malignant Retinal Neoplasm Malignant Tumor Of Retina Neoplasm Of Retina Retinal Tumor Retinal Neoplasm Cancer Of The Retina Malignant Retinal Tumour Malignant Tumour Of Retina Primary Malignant Neoplasm Of Retina
Familial Retinoblastoma	Hereditary Retinoblastoma Retinoblastoma
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-N2252	Licarin A	Inhibitor	99.83%	Unkown
HY-P1640	(Trp63,Trp64)-C3a(63-77)	Agonist	99.23%	Unkown
HY-116295	MRS2690		/	Unkown
HY-116295A	MRS2690 disodium		/	Unkown
HY-139247	pNPS-DHA		/	Unkown
HY-N15708	Dichotomine C	Inhibitor	/	Unkown
HY-P11163	Eumenitin		/	Unkown
HY-RS11730	RBL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N12116	Maceneolignan A	Inhibitor	/	Unkown
HY-RS21415	Rbl2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27934	Rbl2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RBL2	RGD	RGD:3541
Canis familiaris	RBL2	VGNC	VGNC:45403
Macaca mulatta	RBL2	VGNC	VGNC:99582
Bos taurus	RBL2	VGNC	VGNC:33782
Felis catus	RBL2	VGNC	VGNC:69261
Mus musculus	RBL2	MGD	MGI:105085
Others	RBL2	NCBI