Glutaryl-CoA

Glutaryl coenzyme A (1 mmol/liter) does not directly inhibit the activity of respiratory chain complexes I-V in bovine heart submitochondrial particles^[1].

Glutaryl coenzyme A acts as an uncompetitive inhibitor of purified porcine heart α-ketoglutarate dehydrogenase complex with respect to α-ketoglutarate, with a slope inhibitor constant (K_is) of 0.35 mmol/liter^[1].
Glutaryl coenzyme A (1 mmol/liter) is a substrate/product of the E2k (dihydrolipoyl succinyltransferase) subunit of porcine heart KGDHc but does not inhibit the E1k or E3 subunits^[1].
Glutaryl coenzyme A (up to 2 mmol/liter) inhibits purified porcine heart pyruvate dehydrogenase complex to a lesser extent than it inhibits α-ketoglutarate dehydrogenase complex^[1].
Glutaryl coenzyme A (up to 2 mmol/liter) has no significant direct effect on malate dehydrogenase, fumarase, aconitase, or isocitrate dehydrogenase, and only weakly inhibits citrate synthase in purified porcine heart TCA cycle enzyme preparations^[1].
Glutaryl coenzyme A (up to 1 mmol/liter) does not directly inhibit the activities of SCAD, MCAD, or VLCAD in mouse liver homogenates^[1].