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Cat. No.: HY-13847

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GNE-555

GNE-555 is a selective, metabolically stable mTOR inhibitor (K_i=1.5 nM) that also has good oral bioavailability. GNE-555 exhibits antiproliferative activity on PC3 and MCF-7 cells and can be used in cancer research.

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CAS No.: 1428902-71-9
화학식: C₂₆H₃₄N₆O₃
분자량:478.59

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

GNE-555 Chemical Structure

CAS No.: 1428902-71-9

사이즈

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수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All mTOR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	EC₅₀	75 nM Compound: 20, GNE-555	Cytotoxicity against human MCF7 neo/Her2 cells after 3 days by CellTiter-Glo assay Cytotoxicity against human MCF7 neo/Her2 cells after 3 days by CellTiter-Glo assay	[PMID: 23473235]
PC-3	EC₅₀	29 nM Compound: 20, GNE-555	Cytotoxicity against human PC3 cells after 4 days by CellTiter-Glo assay Cytotoxicity against human PC3 cells after 4 days by CellTiter-Glo assay	[PMID: 23473235]

Chemical Information

CAS No. 1428902-71-9
분자량 478.59
화학식 C₂₆H₃₄N₆O₃
SMILES

O=C(NC1=CC=C(C2=NC(N3[C@@H](C)COCC3)=C(C[C@]4([H])CC[C@@]5([H])N4C6COC6)C5=N2)C=C1)NCC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Estrada AA, et al. Pyrimidoaminotropanes as potent, selective, and efficacious small molecule kinase inhibitors of the mammalian target of rapamycin (mTOR). J Med Chem. 2013 Apr 11;56(7):3090-101. [Content Brief]

[2]. Huang G, et al. Applications of oxetanes in drug discovery and medicinal chemistry. Eur J Med Chem. 2023 Dec 5;261:115802. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
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수량:
MCE Japan Authorized Agent:

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Purity:
수량:

GNE-555

All mTOR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

GNE-555 Related Classifications

HY-13847 Related Classifications