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Cat. No.: HY-15882

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GNE-783

GNE-783 is a selective CHK1 inhibitor that enhances the activity of gemcitabine. GNE-783 improves the efficacy of anti-metabolite DNA damage drugs by inactivating S-phase and G2-phase cell cycle checkpoints following DNA damage. GNE-783 selectively enhances the chemical synergy of certain drugs in different tumor types, for example, enhancing the activity of temozolomide only in melanoma cell lines.

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CAS No.: 1200127-66-7
화학식: C₂₂H₂₀N₆
분자량:368.43

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

GNE-783 Chemical Structure

CAS No.: 1200127-66-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Endogenous Metabolite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HT-29	EC₅₀	97.7 nM Compound: 1, GNE-783	Inhibition of CHK1 in human HT29 cells assessed as phosphorylation of histone H3 after 24 hrs by checkpoint abrogation cellular assay Inhibition of CHK1 in human HT29 cells assessed as phosphorylation of histone H3 after 24 hrs by checkpoint abrogation cellular assay	[PMID: 25988399]
HT-29	GI₅₀	>25 μM Compound: 16, GNE-783	Antiproliferative activity against human HT-29 cells assessed as growth inhibition Antiproliferative activity against human HT-29 cells assessed as growth inhibition	[PMID: 25453805]
HT-29	IC₅₀	0.098 μM Compound: 16, GNE-783	Inhibition of ChK1 in human HT-29 cells assessed as phospho-histone H3 by Isobologram assay Inhibition of ChK1 in human HT-29 cells assessed as phospho-histone H3 by Isobologram assay	[PMID: 25453805]

Chemical Information

CAS No. 1200127-66-7
분자량 368.43
화학식 C₂₂H₂₀N₆
SMILES

N#CC1=NC=C2C(C3=CC(C4=CC=C(N5CCN(C)CC5)C=C4)=CN=C3N2)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Identification of preferred chemotherapeutics for combining with a CHK1 inhibitor

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

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수량:

GNE-783

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

GNE-783 Related Classifications

HY-15882 Related Classifications