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Cat. No.: HY-P4092

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HN-1

HN-1 is a tumor-specific internalizing peptide. HN-1 internalizes through receptor-mediated, energy-dependent, Clathrin-mediated endocytosis. HN-1 preferentially binds to invasive head and neck squamous cell carcinoma and is selectively internalized. HN-1 enhances the transfer of liposome-DNA complexes to head and neck squamous cell carcinoma. HN-1 can be used for research on head and neck squamous cell carcinoma.

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CAS No.: 386223-83-2
화학식: C₅₇H₉₆N₁₈O₁₈
분자량:1321.48

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

HN-1 Chemical Structure

CAS No.: 386223-83-2

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

HN-1 is internalized by attached HNSCC cell lines such as MDA177Tu, UMSCC1, SCC-25, CAL-27, and FaDu, but not by suspended HNSCC cells or normal HOK16B/NOE/NHDF cells, via energy-dependent clathrin-mediated endocytosis and endosomal localization^[2].
HN-1 (>500 μM) blocks FITC-labeled HN-1 internal fluorescence in HNSCC cells, supporting specific HN-1-mediated uptake rather than free-dye labeling^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-cancer

Cy5-labeled HN-1-PKCε is taken up by HNSCC xenograft tumors and reduces overall HNSCC tumor growth in mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 386223-83-2
분자량 1321.48
화학식 C₅₇H₉₆N₁₈O₁₈
Sequence

Thr-Ser-Pro-Leu-Asn-Ile-His-Asn-Gly-Gln-Lys-Leu
Sequence Shortening

TSPLNIHNGQKL
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hong FD, et al. Isolation of a peptide for targeted drug delivery into human head and neck solid tumors. Cancer Res. 2000 Dec 1;60(23):6551-6. PMID: 11118031. [Content Brief]

[2]. Hong FU, et al. Tumor specifically internalizing peptide 'HN-1': Targeting the putative receptor retinoblastoma-regulated discoidin domain receptor 1 involved in metastasis. World journal of clinical oncology. 2022 May 24;13(5):323-338.

[3]. Wright CL, et al. Advancing theranostics with tumor-targeting peptides for precision otolaryngology. World journal of otorhinolaryngology - head and neck surgery. 2016 Jun;2(2):98-108.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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