HO 221
HO 221 is an orally active benzoylphenylurea derivative with antitumor activity. HO 221 can inhibit the activity of mammalian DNA polymerase alpha. HO 221 can induce G1 phase arrest. HO 221 can be used for the research of cancer, such as leukemia.
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- CAS No.: 105128-93-6
- 화학식: C18H11BrClN5O5
- 분자량:492.67
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
제품 설명
IC50 & Target
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DNA Polymerase |
Chemical Information
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CAS No. 105128-93-6
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분자량 492.67
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화학식 C18H11BrClN5O5
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SMILES
ClC1=C(OC2=NC=C(Br)C=N2)C=CC(NC(NC(C3=C(C=CC=C3)[N+]([O-])=O)=O)=O)=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Nakajima T, et al. Antitumor activity on murine tumors of a novel antitumor benzoylphenylurea derivative, HO-221. Cancer Chemother Pharmacol. 1991;28(5):351-6. [Content Brief]
[2]. Nakajima T, et al. Mechanism of tumor cell killing by HO-221, a novel antitumor compound. Cancer Chemother Pharmacol. 1990;27(3):199-204. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HO 221 Related Classifications
HY-106787 Related Classifications
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