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Cat. No.: HY-P10136A

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IA9 TFA

Name: IA9 TFA
Brand: MedChemExpress
SKU: HY-P10136A
Price: 125.00 USD
Availability: InStock
Rating: 5 (2 reviews)

(Synonyms: human TREM-2 182-190 TFA)

2 Cited Publications

고객리뷰

Based on 2 publication(s) in Google Scholar

IA9 TFA (human TREM-2 182-190 TFA) is a potent, CNS-penetrant TREM-2 inhibitor. IA9 TFA can diminish the release of proinflammatory cytokines and suppress joint inflammation and damage in a Collagen (HY-P5003)-induced arthritis (CIA) mouse model. IA9 TFA can be used for neuroinflammation PET imaging. IA9 TFA can be used for Rheumatoid arthritis (RA) and neuroinflammation research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity : 98.90%
화학식: C₅₁H₈₈N₁₀O₁₀.xC₂HF₃O₂
분자량:1001.31 (free acid)

보관:

Sealed storage, away from moisture.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

IA9 TFA Chemical Structure

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수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (2)
용액&용해도
- In Vitro
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

TREM-2

All TREM receptor Isoforms :

In Vivo

IA9 (2.5 and 25 mg/kg, i.p., daily for 14 days from day 28) TFA exerts anti-inflammatory and anti-arthritic effects in a CIA mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male DBA/1J mice (7-9 weeks old) subcutaneously injected with type II collagen^[1]
Dosage:

2.5 and 25 mg/kg
Administration:

i.p., daily for 14 days from day 28
Result:

Resulted in an increase in body weight.
Significantly reduced all six-joint mean histopathological parameters compared to vehicle-treated mice at the dose of 25 mg/kg.
Significantly reduced joint damage and bone erosion in CIA in a specific- and dose-dependent manner.
Reduced plasma and joint proinflammatory cytokine (IL-6, IL-1β, TNF-α, CSF-1) levels in a specific and dose-dependent manner.
Significantly reduced the number of inflammatory cells in the synovial membrane of the joints.

Related Protocols :

Chemical Information

Appearance Solid
분자량 1001.31 (free acid)
화학식 C₅₁H₈₈N₁₀O₁₀.xC₂HF₃O₂
Color White to off-white
Synonyms

human TREM-2 182-190 TFA
Sequence

Ile-Phe-Leu-Ile-Lys-Ile-Leu-Ala-Ala
Sequence Shortening

IFLIKILAA
선적

Room temperature in continental US; may vary elsewhere.

보관

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (2)

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Nat Cell Biol

An extracellular vesicle-mediated mitochondrial transfer network critical for testosterone synthesis. [Abstract]

2026 Apr;28(4):707-724. PMID: 41760931
Animals and Zoonoses

2026 Feb 13.

용액&용해도

In Vitro:

DMSO : 6.25 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sigalov AB. Inhibition of TREM-2 Markedly Suppresses Joint Inflammation and Damage in Experimental Arthritis. Int J Mol Sci. 2022;23(16):8857. Published 2022 Aug 9. [Content Brief]

[2]. Zonghua Luo, et al. Development of a Ga-68 Labeled Peptide Tracer Targeting TREM2 for Neuroinflammation PET Imaging. Journal of Nuclear Medicine. Jun 2025, 66 (supplement 1) 251786.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (2)
용액&용해도
- In Vitro
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
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수량:

IA9 TFA

Publications Citing Use of MedChemExpress (MCE) IA9 TFA

All TREM receptor Isoforms