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Cat. No.: HY-184157

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IB15C

IB15C is an ILT3 (LILRB4) inhibitor with a human K_d of 0.92 μM. IB15C binds to a specific ILT3 pocket, disrupts ApoE interaction, and interferes with downstream inhibitory signaling pathways. IB15C reduces SHP1 and SHP2 phosphorylation, suppresses pro-inflammatory cytokine secretion, enhances amyloid uptake, and attenuates NF-κB activation. IB15C can be used for the research of alzheimer's disease.

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화학식: C₂₁H₂₅N₃O₄
분자량:383.44

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

IB15C Chemical Structure

사이즈

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수량

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

LILRB

0.92 μM (Kd)

All Human leukocyte immunoglobulin (Ig)-like receptors (LILR) Isoforms :

LILRB

All NF-κB Isoforms :

In Vitro

IB15C binds to recombinant human ILT3 extracellular domain with submicromolar affinity, showing an apparent K_d of 0.92 μM^[1].
IB15C inhibits the interaction between recombinant human ILT3 extracellular domain and ApoE in an ELISA-based assay with an IC₅₀ of 0.48 μM^[1].
IB15C inhibits the interaction between recombinant human ILT3 extracellular domain and ApoE in a BLI-based real-time assay with an IC₅₀ of 0.64 μM^[1].
IB15C (1-10 μM) reverses ILT3-dependent inhibitory signaling, reduces inflammatory activation, and restores Aβ uptake in human iPSC-derived microglia under Aβ₄₂- and ApoE-driven conditions, with no detectable cytotoxicity at concentrations up to 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 383.44
화학식 C₂₁H₂₅N₃O₄
SMILES

COC1=C(OC)C=CC(C(C)CNC(C2=CC(C(C(C)C)=NO3)=C3N=C2)=O)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Abdel-Rahman SA, et al. High-Throughput CETSA Identifies Small Molecule Modulators of ILT3 (LILRB4) with Functional Activity in Human iPSC-Derived Microglia for Alzheimers Disease. bioRxiv. 2026 May 21.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
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IB15C

All Human leukocyte immunoglobulin (Ig)-like receptors (LILR) Isoforms

All NF-κB Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

IB15C Related Classifications

HY-184157 Related Classifications