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Cat. No.: HY-P991740

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Biologically Validated

IBI-363

Name: IBI-363
Brand: MedChemExpress
SKU: HY-P991740
Price: 850.00 USD
Availability: InStock
Rating: 5 (1 reviews)

고객리뷰

Based on 1 Customer Validation

IBI-363 is a PD-1/IL-2 bispecific antibody with functions of blocking the PD-1/PD-L1 pathway and activating the IL-2 pathway. The IL-2 arm of IBI-363 retains affinity for IL-2Rα but attenuates binding ability to IL-2Rβ and IL-2Rγ to reduce toxicity. The PD-1 binding arm of IBI-363 enables PD-1 blockade and selective delivery of IL-2. IBI-363 can be used in cancer research, such as non-small cell lung cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.92%
분자량:112.48 kDa

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

IBI-363 Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Clinical Trial
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- 신청
- Verified Bioactivity
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Species Reactivity

Human

IC₅₀ & Target^[1]

IL-2

All Interleukin Related Isoforms :

In Vitro

IBI363 is a PD-1/IL-2α-biased bispecific antibody fusion protein designed to block the PD-1 immune checkpoint and reinvigorate exhausted tumor-specific T cells via cis-activation of α-biased IL-2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

5133 [NCBI]

Accession

Q15116

Target

PD-1 & IL-2α

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

PD-1/IL-2 α-bias bispecific antibody

신청

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized PD-1 Protein, Human (HEK293, HY-P7396) can bind IBI-363. The ED₅₀ for this effect is 4.714 ng/mL.

Chemical Information

Appearance Liquid
분자량 112.48 kDa
Color Colorless to light yellow
SMILES

[IBI-363]
선적

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (256 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. Zhou J, et al. MA11. 04 first-in-class PD-1/IL-2 bispecific antibody IBI363 in patients with advanced non-small cell lung cancer in a phase I study[J]. Journal of Thoracic Oncology, 2024, 19(10): S97.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Clinical Trial
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- 신청
- Biological Activity
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

IBI-363

Human IgG4 (S228P) kappa, Isotype Control

Human IgG1 kappa, Isotype Control

SMCC-DM1

Zolbetuximab

All Interleukin Related Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Bioz

IBI-363

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

PBS Buffer (1×)

Human IgG4 (S228P) kappa, Isotype Control

Human IgG1 kappa, Isotype Control

SMCC-DM1

Zolbetuximab

All Interleukin Related Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

IBI-363 Related Classifications

HY-P991740 Related Classifications

Bioz