JNJ525
Based on 1 Customer Validation
JNJ525 is a TNFα inhibitor with IC50 values of 1.2 μM and 1.1 μM against TNFR1 and TNFR2, respectively. JNJ525 forms ordered aggregates and induces quaternary structural transition of TNFα, thereby blocking the protein-protein interaction between TNFα and its receptors. The inhibitory activity of JNJ525 is completely lost in the presence of 0.1% Triton X-100.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.93%
- CAS No.: 2092913-64-7
- 화학식: C31H30N8
- 분자량:514.62
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
JNJ525 (Range; 1 h (with TNFα), 2 h (with receptor)) inhibits the protein-protein interaction between soluble human TNFα and its receptors TNFR1 and TNFR2 with apparent IC50 values of 1.2 μM and 1.1 μM, respectively, and this inhibitory activity is abrogated by 0.1% Triton X-100[1].
JNJ525 (Range; 30 min) forms aggregates with a critical aggregation concentration of 1 μM in both assay and crystallization buffers, and this aggregation is prevented by 0.1% Triton X-100[1].
JNJ525 (50 μM; 3 h) induces soluble human TNFα to shift from a trimer to a dimer associated with ~13 JNJ525 molecules, as measured by sedimentation velocity analytical ultracentrifugation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2092913-64-7
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Appearance Solid
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분자량 514.62
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화학식 C31H30N8
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Color White to off-white
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SMILES
NC1=NC=CC(N(CC2=CC=CC=C2)C3=C(C4=CC(C5=CN=C(N6CCNCC6)N=C5)=CC=C4)C=CC=C3)=N1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 5 mg/mL (9.72 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9432 mL | 9.7159 mL | 19.4318 mL | 48.5795 mL |
| 5 mM | 0.3886 mL | 1.9432 mL | 3.8864 mL | 9.7159 mL |
JNJ525 Related Classifications
HY-124339 Related Classifications
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