KARS-IN-1
KARS-IN-1 (152) is a AKR1C3 dependent KARS inhibitor with an AC50 of 9.1 nM for human KARS. KARS-IN-1 shows anti-proliferative activity in H460 (NRF2 pathway mutant cell line with high AKR1C3 expression) and Hara (NRF2 pathway wild type cell line with low AKR1C3 expression), with AC50 values ??of 21 nM and 16 nM, respectively. KARS-IN-1 can be used for the study of non-small cell lung cancer (NSCLC).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 2579083-99-9
- 화학식: C21H23F2N3O2
- 분자량:387.42
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
Chemical Information
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CAS No. 2579083-99-9
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분자량 387.42
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화학식 C21H23F2N3O2
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SMILES
FC(C=C1)=CC=C1CNC(N(CC2)CCC32C[C@@H](O)C4=CC(F)=CC=C4N3)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KARS-IN-1 Related Classifications
HY-180562 Related Classifications
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