L-NIO
Based on 2 publication(s) in Google Scholar
L-NIO is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively. L-NIO induces a consistentfocal ischemic infarctin rats.
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- CAS No.: 36889-13-1
- 화학식: C7H15N3O2
- 분자량:173.21
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) L-NIO
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Biological Activity
Ki: 1.7 μM (nNOS), 3.9 μM (eNOS), 3.9 μM (iNOS)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW | IC50 |
9 μM
Compound: L-NIO
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Compound was evaluated for inhibitory activity against iNOS obtained from RAW 264.7 cells.
Compound was evaluated for inhibitory activity against iNOS obtained from RAW 264.7 cells.
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[PMID: 9873655] |
L-NIO is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 36889-13-1
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분자량 173.21
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화학식 C7H15N3O2
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SMILES
CC(NCCC[C@@H](C(O)=O)N)=N
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Mol Gastroenterol Hepatol
2021;11(3):683-696. PMID: 33075564 -
Eur J Pharmacol
Bradykinin modulates endothelin-1-enhanced and monocrotaline-induced pulmonary arterial hypertension-associated arrhythmogenesis in rabbit right ventricular outflow tract via a nitric oxide-dependent pathway. [Abstract]2026 Apr 24:178896. PMID: 42035941
순도&문서
References
[1]. Babu BR, et al. N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. J Biol Chem. 1998 Apr 10;273(15):8882-9. [Content Brief]
[2]. Van Slooten AR, et al. L-NIO as a novel mechanism for inducing focal cerebral ischemia in the adult rat brain. J Neurosci Methods. 2015 Apr 30;245:44-57. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L-NIO Related Classifications
HY-100986B Related Classifications
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