Cat. No.: HY-N6948

Linalyl acetate

1 Cited Publications

고객리뷰

Based on 1 publication(s) in Google Scholar

Linalyl acetate is the principal components of many plant essential oils. Linalyl acetate exhibits anti-anxiety, anti-inflammatory, anti-diabetic, anti-stress, and cardiovascular-regulatory effects. Linalyl acetate is orally active.

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Purity: 98.80%
CAS No.: 115-95-7
화학식: C₁₂H₂₀O₂
분자량:196.29

보관:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Linalyl acetate Chemical Structure

CAS No.: 115-95-7

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Biological Activity
- 제품 설명
- In Vivo
- Clinical Trial
Chemical Information
Publications (1)
용액&용해도
- In Vitro
- In Vivo
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vivo

Linalyl acetate (400 mg/kg, po, once daily for 15 days) stimulates the central nervous system, exhibits sedative and anti-anxiety effect in mouse models^[2].
Linalyl acetate (1-100 mg/kg, ip, single dose) reduces the heart rate and LDH activity, relieves vasoconstriction. Linalyl acetate alleviates the cardiovascular and cell damage caused by acute nicotine exposure in mouse models^[3].
Linalyl acetate (100 mg/kg, ip, twice weekly for 5 weeks) regulates the expression of inflammatory mediators, prevents mitochondrial dysfunction, exhibits anti-inflammatory and anti-fibrotic effects in rats collagen II-induced arthritis (CIA) models^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Swiss albino mouse model^[2].
Dosage:

400 mg/kg
Administration:

po, once daily for 15 days
Result:

Increased the time and number of entries in the open arm or bright chamber in the elevated plus maze and light-dark box tests.
Increased the motor activity in the open field test and the activity photoelectric instrument test.

Animal Model:

Acute nicotine exposure in mouse models^[3]
Dosage:

1-100 mg/kg
Administration:

ip, single dose
Result:

Reduced LDH activity, inhibited relaxation of mouse aortic rings, and improved the nitric oxide (NO) level in serum.

Animal Model:

Collagen II-induced arthritis (CIA) rats models^[4]
Dosage:

100 mg/kg
Administration:

ip, twice weekly for 5 weeks
Result:

Inhibited the increase in hind paw thickness, reduced serum IL-6 level, increased the gastrocnemius muscle weight and fiber cross-sectional area.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 115-95-7
Appearance Liquid (Density: 0.8997 g/cm³)
분자량 196.29
화학식 C₁₂H₂₀O₂
Color Colorless to light yellow
SMILES

CC(OC(CC/C=C(C)\C)(C)C=C)=O
Structure Classification
- Others
Initial Source
- Plants
- Labiatae
선적

Room temperature in continental US; may vary elsewhere.

보관

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Cell Rep

A neural circuit for lavender-essential-oil-induced antinociception. [Abstract]

2024 Oct 3;43(10):114800. PMID: 39365703

용액&용해도

In Vitro:

DMSO : 100 mg/mL (509.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.0945 mL

25.4725 mL

50.9450 mL

5 mM

1.0189 mL

5.0945 mL

10.1890 mL

10 mM

0.5095 mL

2.5473 mL

5.0945 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (12.74 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (12.74 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (12.74 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. A.T. Peana, et al. Anti-inflammatory activity of linalool and linalyl acetate constituents of essential oils,Phytomedicine. 2002 Dec;9(8):721-6. [Content Brief]

[2]. Rani M, et al. Evaluation of antianxiety activity of Linalyl acetate in Swiss albino Mice[J]. Ann Romanian Soc Cell Biol, 2022, 26(1): 3470-3482.

[3]. Kim JR, et al., Cardiovascular effects of linalyl acetate in acute nicotine exposure. Environ Health Prev Med. 2017 Apr 24;22(1):42. [Content Brief]

[4]. Seo E, et al., Linalyl acetate as a potential preventive agent against muscle wasting in rheumatoid arthritis rats chronically exposed to nicotine. J Pharmacol Sci. 2021 Sep;147(1):27-32. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	5.0945 mL	25.4725 mL	50.9450 mL	127.3626 mL
	5 mM	1.0189 mL	5.0945 mL	10.1890 mL	25.4725 mL
	10 mM	0.5095 mL	2.5473 mL	5.0945 mL	12.7363 mL
	15 mM	0.3396 mL	1.6982 mL	3.3963 mL	8.4908 mL
	20 mM	0.2547 mL	1.2736 mL	2.5473 mL	6.3681 mL
	25 mM	0.2038 mL	1.0189 mL	2.0378 mL	5.0945 mL
	30 mM	0.1698 mL	0.8491 mL	1.6982 mL	4.2454 mL
	40 mM	0.1274 mL	0.6368 mL	1.2736 mL	3.1841 mL
	50 mM	0.1019 mL	0.5095 mL	1.0189 mL	2.5473 mL
	60 mM	0.0849 mL	0.4245 mL	0.8491 mL	2.1227 mL
	80 mM	0.0637 mL	0.3184 mL	0.6368 mL	1.5920 mL
	100 mM	0.0509 mL	0.2547 mL	0.5095 mL	1.2736 mL

Keywords

Linalyl acetate

1 Cited Publications

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Linalyl acetate

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Publications Citing Use of MedChemExpress (MCE) Linalyl acetate

Biological Activity

Chemical Information

Publications (1)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

Linalyl acetate Related Classifications

HY-N6948 Related Classifications