Melitracen
Melitracen (Melitracene) is an orally active tricyclic antidepressant and it is also a bipolar thymoleptic with activating properties. Melitracen inhibits 3H-5-HT and 14H-5-HT with IC50s of 670 nM and 5500 nM, respectively. Melitracen can be used for the research of depression and anxiety.
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- CAS No.: 5118-29-6
- 화학식: C21H25N
- 분자량:291.43
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All 5-HT Receptor Isoforms
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Biological Activity
IC50: 670 nM (3H-5-HT), 5500 nM (14H-5-HT)[2]
Melitracen (0-10 μM; 10 min) inhibits 3H-5-HT in synaptosomes and 14H-5-HT in blood platelets[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Synaptosomes and blood platelets from male albino rats
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Concentration:0-10 μM
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Incubation Time:10 min
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Result:Inhibited 3H-5-HT in synaptosomes and 14H-5-HT in blood platelets with IC50s of 670 nM and 5500 nM, respectively.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male and female Wistar rats[1]
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Dosage:10, 30 and 90 mg/kg
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Administration:Oral gavage; 10-90 mg/kg daily; for 3 months
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Result:Showed aggressive behaviour, excitability, body and livers weight gain, and livers slight atrophic with increasing dose to rats.
Chemical Information
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CAS No. 5118-29-6
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분자량 291.43
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화학식 C21H25N
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SMILES
CN(CC/C=C1C2=C(C(C)(C3=CC=CC=C\13)C)C=CC=C2)C
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Synonyms
Melitracene; N 7001; Trausabun
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Shimamoto K, et al. Relationship between the restriction of food intake and Melitracen, an antidepressant, in the rat. Acta Sch Med Univ Kioto. 1967 Jul;40(1):25-37. [Content Brief]
[2]. Hyttel J. Effect of a specific 5-HT uptake inhibitor, citalopram (Lu 10-171), on 3H-5-HT uptake in rat brain synaptosomes in vitro. Psychopharmacology (Berl). 1978 Dec 15;60(1):13-8. doi: 10.1007/BF00429172. PMID: 104340. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Melitracen Related Classifications
HY-121778 Related Classifications
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