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Cat. No.: HY-N4329

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Nidulalin A

Nidulalin A is a DNA topoisomerase II inhibitor with an IC₅₀ of 2.2 μM. Nidulalin A has an IC₅₀ of 172 μM for DNA topoisomerase I. Nidulalin A has certain cytotoxicity.

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CAS No.: 162901-86-2
화학식: C₁₆H₁₄O₆
분자량:302.28

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Nidulalin A Chemical Structure

CAS No.: 162901-86-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Nidulalin A is a DNA topoisomerase II inhibitor with an IC₅₀ of 2.2 μM. Nidulalin A has an IC₅₀ of 172 μM for DNA topoisomerase I. Nidulalin A has certain cytotoxicity^[1].

All Topoisomerase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.14 μM Compound: 1 (Nidulalin A)	In vitro cytotoxic activity against human cancer cell line HCT116 by using MTT assay In vitro cytotoxic activity against human cancer cell line HCT116 by using MTT assay	[PMID: 10509910]
K562	IC₅₀	0.32 μM Compound: 1 (Nidulalin A)	In vitro cytotoxic activity against human cancer cell line K562 by using MTT assay In vitro cytotoxic activity against human cancer cell line K562 by using MTT assay	[PMID: 10509910]
P388	IC₅₀	0.024 μM Compound: 1 (Nidulalin A)	In vitro cytotoxic activity against murine cancer cell line P388 by using MTT assay In vitro cytotoxic activity against murine cancer cell line P388 by using MTT assay	[PMID: 10509910]

Chemical Information

CAS No. 162901-86-2
분자량 302.28
화학식 C₁₆H₁₄O₆
SMILES

COC([C@]12C(C(C3=C(O)C=C(C)C=C3O2)=O)=CC=C[C@H]1O)=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Microorganisms
Penicillium sp. AJ117292
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sato S, et al. Inhibition of DNA topoisomerases by nidulalin A derivatives. Biol Pharm Bull. 2000 Apr;23(4):511-2. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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Nidulalin A

All Topoisomerase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Nidulalin A Related Classifications

HY-N4329 Related Classifications