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Cat. No.: HY-129679

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NMS-P953

NMS-P953 (compound 28) is an orally active JAK2 inhibitor (IC₅₀=0.008 μM) with antitumor activity.

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CAS No.: 1403679-33-3
화학식: C₁₆H₁₁ClF₃N₅O
분자량:381.74

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

NMS-P953 Chemical Structure

CAS No.: 1403679-33-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

NMS-P953 (compound 28) is an orally active JAK2 inhibitor (IC₅₀=0.008 μM) with antitumor activity^[1].

IC₅₀ & Target^[1]

JAK2

0.008 μM (IC₅₀)

All JAK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	1.47 μM Compound: 28	Antiproliferative activity against human A2780 cells after 72 hrs by Cell Titer-Glo assay Antiproliferative activity against human A2780 cells after 72 hrs by Cell Titer-Glo assay	[PMID: 25009002]

Chemical Information

CAS No. 1403679-33-3
분자량 381.74
화학식 C₁₆H₁₁ClF₃N₅O
SMILES

O=C(C1=C(C2=CC(C(F)(F)F)=CC=C2Cl)NC(C3=NC(N)=NC=C3)=C1)N
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Brasca M G, et al. Pyrrole-3-carboxamides as potent and selective JAK2 inhibitors[J]. Bioorganic & Medicinal Chemistry, 2014, 22(17): 4998-5012. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
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NMS-P953

All JAK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

NMS-P953 Related Classifications

HY-129679 Related Classifications