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Cat. No.: HY-122079

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NSC1011

NSC1011 is a potent Ras converting enzyme 1 endoprotease (Rce1) inhibitor with an IC₅₀ value of 6.9 µM for HsRce1 (crystal structure of the human Rce1). NSC1011 induces mislocalizing EGFR-H-Ras, EGFR-N-Ras, and EGFR-K-Ras.

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CAS No.: 5335-97-7
화학식: C₂₃H₁₈N₂O₃
분자량:370.40

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

NSC1011 Chemical Structure

CAS No.: 5335-97-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

IC₅₀: 6.9 µM (Rce1)^[1]

All Ras Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
U-87MG ATCC	IC₅₀	>10 μM Compound: NC269, NSC 1011	Cytotoxicity against human U-87 MG cells assessed as growth inhibition measured after 72 hrs by MTT assay Cytotoxicity against human U-87 MG cells assessed as growth inhibition measured after 72 hrs by MTT assay	[PMID: 32830969]

In Vitro

NSC1011 (25 µM; 20 h) induces mislocalizing EGFR-H-Ras, EGFR-N-Ras, and EGFR-K-Ras in HCT-116 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 5335-97-7
분자량 370.40
화학식 C₂₃H₁₈N₂O₃
SMILES

O=C(C1=CC=C(C=C1)NC(C2=CC=CC=C2)C3=CC=C4C=CC=NC4=C3O)O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mohammed I, et al. 8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells. Bioorg Med Chem. 2016 Jan 15;24(2):160-78. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
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NSC1011

All Ras Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

NSC1011 Related Classifications

HY-122079 Related Classifications