NTQ2494
NTQ2494 is a potent and orally active AXL kinase inhibitor with an IC50 of 4.89 nM. NTQ2494 inhibits AXL kinase catalytic activity. NTQ2494 suppresses tumor growth in mouse xenograft models. NTQ2494 can be used for the research of advanced hematological malignancies, solid tumors.
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- CAS No.: 2750027-59-7
- 화학식: C29H37ClN5O2P
- 분자량:554.06
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Axl 4.89 nM (IC50) |
NTQ2494 (0-10 μM; 72 h) inhibits proliferation of MV-4-11, MOLM-13, K-562, KATO III, HCT-116, SW48, MIA PaCa-2, and TOV-21G cancer cells with IC50 values of 0.007, 0.008, 0.030, 0.023, 0.100, 0.019, 0.033, and 0.099 μM[1].
NTQ2494 (1-100 μM) inhibits hERG channels in HEK-293-hERG cells with an IC50 of 36.49 μM, indicating low cardiotoxicity risk[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female nude mice (18-20 g) subcutaneously inoculated with MV-4-11 cells[1]
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Dosage:2.5; 5; 10 mg/kg
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Administration:p.o.; once daily; 21 days
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Result:Achieved a tumor growth inhibition (TGI) rate of 46% at 2.5 mg/kg.
Achieved a TGI rate of 91% at 5 mg/kg.
Achieved a TGI rate of 108% at 10 mg/kg.
Showed no significant changes in body weight across all dose.
Chemical Information
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CAS No. 2750027-59-7
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분자량 554.06
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화학식 C29H37ClN5O2P
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SMILES
ClC1=C(NC2=CC=C(COC)C=C2P(C)(C)=O)N=C(NC3=CC(CC[C@@H](N4CCCC4)CC5)=C5C=C3)N=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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