OM99-2
OM99-2, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a Ki value of 9.58 nM. OM99-2 is significantly advanced the development of BACE1 inhibitor. OM99-2 has the potential for the research of the Alzheimer's disease.
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- CAS No.: 314266-76-7
- 화학식: C41H64N8O14
- 분자량:892.99
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
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HY-16759A
Verubecestat TFABACE1/2 Inhibitor -
HY-10472
LY2811376BACE1 Inhibitor -
HY-13240A
LY2886721 hydrochlorideBACE1 Inhibitor -
HY-10133
β-Secretase Inhibitor IVBACE-1 Inhibitor -
HY-136742
BACE2-IN-1BACE2 Inhibitor -
HY-12938
AMG-8718BACE1 Inhibitor -
HY-100182
BACE1-IN-1BACE1/2 Inhibitor -
HY-100740C
(1α,1'S,4β)-LanabecestatLanabecestat Enantiomer -
HY-10472R
LY2811376 (Standard)Reference Standard -
HY-100182R
BACE1-IN-1 (Standard)Reference Standard -
HY-10133R
β-Secretase Inhibitor IV (Standard)BACE-1 Inhibitor -
HY-100740CR
(1α,1'S,4β)-Lanabecestat (Standard)Lanabecestat Enantiomer
Biological Activity
제품 설명
IC50 & Target
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BACE1 |
In Vitro
Memapsin 2 (BACE) is an aspartyl protease known as beta-secretase that acts on the production of the beta-amyloid peptide in the human brain[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 314266-76-7
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분자량 892.99
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화학식 C41H64N8O14
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
순도&문서
References
[1]. Ghosh AK, et al. Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase). J Am Chem Soc. 2000;122(14):3522-3523. [Content Brief]
[2]. Zhao J, et al. Targeting Amyloidogenic Processing of APP in Alzheimer's Disease. Front Mol Neurosci. 2020;13:137. Published 2020 Aug 4. [Content Brief]
[3]. Dash C, et al. Aspartic peptidase inhibitors: implications in drug development. Crit Rev Biochem Mol Biol. 2003;38(2):89-119. [Content Brief]
[4]. Park H, et al. Determination of the active site protonation state of beta-secretase from molecular dynamics simulation and docking experiment: implications for structure-based inhibitor design. J Am Chem Soc. 2003;125(52):16416-16422. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
OM99-2 Related Classifications
HY-P2713 Related Classifications
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