PD 119819
PD 119819 is a highly selective benzopyran-4-one brain dopamine autoreceptor agonist. PD 119819, a heterocyclic piperazine, inhibits spontaneous locomotor activity and brain dopamine synthesis.
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- CAS No.: 105277-43-8
- 화학식: C21H25Cl2N3O3
- 분자량:438.35
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All Dopamine Receptor Isoforms
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Biological Activity
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Dopamine Receptor |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Cynomolgus monkey[1]
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Dosage:5~80 mg/kg
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Administration:Nasogastric intubation
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Result:Made monkeys show marked increases in alanine aminotransferase levels and a moderate increase in ornithine carbamyltransferase levels at the initial sampling interval after doses of 5 mg/kg with peak levels occurring after doses of 20 or 60 mg/kg, while lower values were evident after doses of 80 mg/kg.
Chemical Information
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CAS No. 105277-43-8
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분자량 438.35
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화학식 C21H25Cl2N3O3
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SMILES
O=C1C=COC2=CC(OCCCN3CCN(CC3)C4=NC=CC=C4)=CC=C12.[H]Cl.[H]Cl
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Macallum GE, et al. Renal and hepatic toxicity of a benzopyran-4-one in the Cynomolgus monkey. Toxicology. 1989;59(1):97-108. [Content Brief]
[2]. Jaen JC, et al. Dopamine autoreceptor agonists as potential antipsychotics. 2. (Aminoalkoxy)-4H-1-benzopyran-4-ones. J Med Chem. 1991;34(1):248-256. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PD 119819 Related Classifications
HY-118402 Related Classifications
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