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Cat. No.: HY-N13095

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(+)-Plakevulin A

(+)-Plakevulin A (Plakevulin A) is an oxylipin and can be isolated from an Okinawan sponge Plakortis sp. (+)-Plakevulin A inhibits the enzymatic activity of DNA polymerases α and δ. (+)-Plakevulin A induces apoptosis and shows anticancer activity.

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CAS No.: 518035-27-3
화학식: C₂₃H₄₂O₄
분자량:382.58

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

(+)-Plakevulin A Chemical Structure

CAS No.: 518035-27-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

DNA Polymerase

All DNA/RNA Synthesis Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	11.5 μM Compound: (+)-1	Cytotoxicity against human HeLa cells assessed as inhibition of cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as inhibition of cell viability incubated for 24 hrs by MTT assay	[PMID: 38996938]
HL-60	IC₅₀	2.02 μM Compound: (+)-1	Cytotoxicity against human HL-60 cells assessed as inhibition of cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human HL-60 cells assessed as inhibition of cell viability incubated for 24 hrs by MTT assay	[PMID: 38996938]
HL-60	IC₅₀	2.63 μM Compound: (+)-1	Cytotoxicity against human HL-60 cells assessed as inhibition of cell viability incubated for 48 hrs by WST-8 assay Cytotoxicity against human HL-60 cells assessed as inhibition of cell viability incubated for 48 hrs by WST-8 assay	[PMID: 38996938]
MC3T3-E1	IC₅₀	12.38 μM Compound: (+)-1	Cytotoxicity against mouse MC3T3-E1 cells assessed as inhibition of cell viability incubated for 24 hrs by MTT assay Cytotoxicity against mouse MC3T3-E1 cells assessed as inhibition of cell viability incubated for 24 hrs by MTT assay	[PMID: 38996938]
MRC5	IC₅₀	>15 μM Compound: (+)-1	Cytotoxicity against human MRC5 cells assessed as inhibition of cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human MRC5 cells assessed as inhibition of cell viability incubated for 24 hrs by MTT assay	[PMID: 38996938]

Chemical Information

CAS No. 518035-27-3
분자량 382.58
화학식 C₂₃H₄₂O₄
SMILES

COC([C@H]1[C@@](O)(C=C[C@@H]1O)CCCCCCCCCCCCCCCC)=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Animals
Okinawan sponge Plakortis sp.
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kabasawa M, et al . Plakevulin A induces apoptosis and suppresses IL-6-induced STAT3 activation in HL60 cells. Bioorg Med Chem Lett. 2024 Sep 15;110:129886. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

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(+)-Plakevulin A

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

(+)-Plakevulin A Related Classifications

HY-N13095 Related Classifications