Polythiazide
Based on 1 Customer Validation
Polythiazide is a potent and orally active thiazide diuretic agent that has antihypertensive effect. Polythiazide can decrease edema and decrease blood pressure. Polythiazide also has phototoxicity.
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- Purity: 98.63%
- CAS No.: 346-18-9
- 화학식: C11H13ClF3N3O4S3
- 분자량:439.88
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Polythiazide (500 μM, 1 min) induces significant phototoxic NHIK 3025 cell death under Bluelight 2000 apparatus (Ex: 325 nM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Polythiazide (oral administration, 0.4 mg/kg) shows diuretic and saluretic effects in hypertensive dogs and rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Cholesterol-fed C57BL/cdJ mice[3]
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Dosage:10 mg/kg
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Administration:Oral gavage, daily for 5 days
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Result:Caused approximately 13% rise in total plasma cholesterol levels, and increased non-HDL lipoprotein fraction.
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Animal Model:Hypertensive dogs[1]
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Dosage:0.4 mg/kg
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Administration:Oral administration, daily for 5 days
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Result:Increased in excretion of sodium and chloride.
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Animal Model:Hypertensive rats[1]
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Dosage:0.05, 0.1, 0.2, 0.4 mg/kg
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Administration:Oral administration, twice a day for 3 days.
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Result:Displayed natriuretic and chloruretic effects.
Chemical Information
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CAS No. 346-18-9
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Appearance Solid
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분자량 439.88
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화학식 C11H13ClF3N3O4S3
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Color White to off-white
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SMILES
O=S(C1=C(Cl)C=C(C2=C1)NC(CSCC(F)(F)F)N(C)S2(=O)=O)(N)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
순도&문서
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. A SCRIABINE, et al. Pharmacological studies with polythiazide, a new diuretic and antihypertensive agent. Proc Soc Exp Biol Med. 1961 Aug-Sep;107:864-72. [Content Brief]
[2]. E Selvaag, et al. Phototoxicity due to sulphonamide derived oral antidiabetics and diuretics: investigations in a cell culture model. Photodermatol Photoimmunol Photomed. 1996 Feb;12(1):1-6. [Content Brief]
[3]. M N Krupp, et al. Effects of doxazosin and other antihypertensives on serum lipid levels and lipoprotein lipase in the C57BR/cdJ mouse. J Cardiovasc Pharmacol. 1989;13 Suppl 2:S11-8; discussion S18-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Polythiazide Related Classifications
HY-16403 Related Classifications
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