CD84
CD84 is a self-binding member of the SLAM family, carrying two extracellular Ig-like domains and a cytoplasmic tail with tyrosine-based motifs that recruit SAP and EAT-2 adaptors. Homophilic CD84-CD84 interactions between cells strengthen adhesion and fine-tune activation signals in T, B, and NK cells. The receptor is expressed broadly across hematopoietic cells, with strong surface levels on B cells, monocytes, and platelets, and it has drawn attention in the stem cell field as part of a marker combination used to enrich human hematopoietic stem cells from mobilized peripheral blood. Studies in lupus models associate altered CD84 expression with B cell hyperactivity. Recombinant CD84 is applied in homophilic-binding and adaptor-recruitment assays.
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CD84 Recombinant Proteins (7)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 화학식: Human
- 분자량: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
