PXS 25
PXS 25 is a cation-independent mannose 6-phosphate receptor (CI-M6PR) inhibitor that inhibits CI-M6PR-mediated activation of latent TGF-β1. PXS 25 inhibits conversion of high glucose-induced latent TGF-β1 to active TGF-β1 in proximal tubule cells under normoxic conditions. PXS 25 suppresses high glucose-induced fibronectin, collagen IV production, and phosphorylated Smad 2 in proximal tubule cells under normoxic conditions. PXS 25 has antifibrotic properties in skin fibroblasts. PXS 25 can be used for the research of diabetic nephropathy.
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- CAS No.: 798546-78-8
- 화학식: C15H23O8P
- 분자량:362.31
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
PXS 25 (1-200 µM; 72 h) inhibits high glucose-induced activation of latent TGF-β1, downstream Smad2 signaling, and extracellular matrix production in normoxic HK-2 cells but does not affect hypoxia-related responses[1].
PXS 25 (1-1000 µM; 72 h) shows no cytotoxic effect on HK-2 cells in normoxic or hypoxic conditions with 5 mM or 30 mM D-glucose (HY-B0389)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HK-2 cells
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Concentration:1 μM, 10 μM, 100 μM, 200 μM, 1000 μM
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Incubation Time:72 h
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Result:Exhibited no cytotoxic effect on HK-2 cells cultured in 5 mM or 30 mM D-glucose under normoxic or hypoxic conditions at concentrations up to 1000 μM.
Chemical Information
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CAS No. 798546-78-8
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분자량 362.31
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화학식 C15H23O8P
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SMILES
O=P(O)(O)CC[C@H]([C@H]([C@@H]([C@@H]1O)O)O)O[C@@H]1OC2=C(C=C(C=C2)C)C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PXS 25 Related Classifications
HY-181430 Related Classifications
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- PXS 25
- 798546-78-8
- PXS25
- PXS-25
- TGF-beta/Smad
- Smad signaling
- extracellular matrix production
- phosphorylated Smad 2
- diabetic nephropathy
- CI-M6PR
- fibronectin
- cation-independent mannose 6-phosphate receptor
- M6P-containing proteins
- TGF-β?
- collagen IV
- D-glucose
- skin fibroblasts
- HK-2 cells
- hypoxic conditions
- proximal tubule cells
- normoxic conditions
- Inhibitor
- inhibitor
- inhibit