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Cat. No.: HY-114061

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(R)-FTY 720P

Name: (R)-FTY 720P
Brand: MedChemExpress
SKU: HY-114061
Price: 320.00 USD
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(R)-FTY 720P is the R-isomer of FTY 720P. (R)-FTY 720P has less potent binding affinities to S1P_1,3,4,5 than (S)-Isomer (HY-15382).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 402616-23-3
화학식: C₁₉H₃₄NO₅P
분자량:387.45

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

(R)-FTY 720P Chemical Structure

CAS No.: 402616-23-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

(R)-FTY 720P is the R-isomer of FTY 720P. (R)-FTY 720P has less potent binding affinities to S1P_1,3,4,5 than (S)-Isomer (HY-15382)^[1].

All LPL Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	0.3 nM Compound: 2	Activity at human S1P1 receptor expressed in CHO cells by [35S]GTPgammaS binding assay Activity at human S1P1 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	[PMID: 15615513]
CHO	EC₅₀	>10000 nM Compound: (R)-5	Agonism of human S1P-2 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand Agonism of human S1P-2 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand	[PMID: 16078855]
CHO	EC₅₀	0.68 nM Compound: 2	Activity at human recombinant S1P1 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay Activity at human recombinant S1P1 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay	[PMID: 17070046]
CHO	EC₅₀	1.7 nM Compound: 2	Activity at human recombinant S1P3 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay Activity at human recombinant S1P3 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay	[PMID: 17070046]
CHO	EC₅₀	18.6 nM Compound: 2	Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay	[PMID: 17070046]
CHO	EC₅₀	2.9 nM Compound: 2	Activity at human recombinant S1P5 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay Activity at human recombinant S1P5 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay	[PMID: 17070046]
CHO	EC₅₀	0.14 nM Compound: FTY720-P	Agonist activity at human S1P1 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding Agonist activity at human S1P1 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding	[PMID: 20153186]
CHO	EC₅₀	0.46 nM Compound: FTY720-P	Agonist activity at human S1P5 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding Agonist activity at human S1P5 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding	[PMID: 20153186]
CHO	EC₅₀	0.7 nM Compound: FTY720-P	Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding	[PMID: 20153186]
CHO	EC₅₀	2.5 nM Compound: FTY720-P	Agonist activity at human S1P3 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding Agonist activity at human S1P3 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding	[PMID: 20153186]
CHO	IC₅₀	0.16 nM Compound: FTY720-P	Displacement of [33P]-S1P1 from human S1P1 receptor expressed in CHO cells Displacement of [33P]-S1P1 from human S1P1 receptor expressed in CHO cells	[PMID: 20153186]
CHO	IC₅₀	>22000 nM Compound: FTY720-P	Agonist activity at human S1P2 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding Agonist activity at human S1P2 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding	[PMID: 20153186]
CHO	EC₅₀	35.1 nM Compound: 3, FTY720-P	Agonist activity at human S1P3 receptor expressed in CHO cells preincubated for 2 hrs before IP1 addition by IP1-HTRF assay Agonist activity at human S1P3 receptor expressed in CHO cells preincubated for 2 hrs before IP1 addition by IP1-HTRF assay	[PMID: 25072873]
CHO	EC₅₀	9.1 nM Compound: 3, FTY720-P	Agonist activity at human S1P1 receptor expressed in CHO cells preincubated for 2 hrs before IP1 addition by IP1-HTRF assay Agonist activity at human S1P1 receptor expressed in CHO cells preincubated for 2 hrs before IP1 addition by IP1-HTRF assay	[PMID: 25072873]
CHO	EC₅₀	11 nM Compound: FTY720-phosphate	Agonist activity at S1P5 receptor (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation by GTPgammaS binding assay Agonist activity at S1P5 receptor (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation by GTPgammaS binding assay	[PMID: 26509640]
CHO	EC₅₀	3.4 nM Compound: FTY720-phosphate	Agonist activity at S1P5 receptor (unknown origin) expressed in CHO cell membranes after 30 mins by GTPgammaS binding assay Agonist activity at S1P5 receptor (unknown origin) expressed in CHO cell membranes after 30 mins by GTPgammaS binding assay	[PMID: 26509640]
CHO	EC₅₀	0.005 nM Compound: 1-P; FTY-P	Agonist activity at human S1P1 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by HTRF analysis Agonist activity at human S1P1 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by HTRF analysis	[PMID: 26985316]
CHO	EC₅₀	0.0056 nM Compound: 1-P; FTY-P	Agonist activity at human S1P1 receptor expressed in CHO cells assessed as ERK phosphorylation after 7 mins by alphaLISA Agonist activity at human S1P1 receptor expressed in CHO cells assessed as ERK phosphorylation after 7 mins by alphaLISA	[PMID: 26985316]
CHO	EC₅₀	0.07 nM Compound: 1-P; FTY-P	Agonist activity at human S1P1 receptor expressed in CHO cells co-expressing GFP assessed as cellular internalization after 45 mins by Hoechst assay Agonist activity at human S1P1 receptor expressed in CHO cells co-expressing GFP assessed as cellular internalization after 45 mins by Hoechst assay	[PMID: 26985316]
CHO	IC₅₀	0.014 nM Compound: 1-P; FTY-P	Displacement of 33-P-S1P from from human S1P receptor expressed in CHO cell membranes after 50 mins by scintillation counting Displacement of 33-P-S1P from from human S1P receptor expressed in CHO cell membranes after 50 mins by scintillation counting	[PMID: 26985316]
CHO	EC₅₀	14 nM Compound: 3, FTY-720P	Agonist activity at S1P1 receptor (unknown origin) expressed in CHO cells preincubated for 2 hrs followed by D2-labeled IP1 and Ab-Cryp addition measured after 1 hr by fluorescence assay Agonist activity at S1P1 receptor (unknown origin) expressed in CHO cells preincubated for 2 hrs followed by D2-labeled IP1 and Ab-Cryp addition measured after 1 hr by fluorescence assay	10.1039/C3MD00079F
CHO	EC₅₀	44 nM Compound: 3, FTY-720P	Agonist activity at S1P3 receptor (unknown origin) expressed in CHO cells preincubated for 2 hrs followed by D2-labeled IP1 and Ab-Cryp addition measured after 1 hr by fluorescence assay Agonist activity at S1P3 receptor (unknown origin) expressed in CHO cells preincubated for 2 hrs followed by D2-labeled IP1 and Ab-Cryp addition measured after 1 hr by fluorescence assay	10.1039/C3MD00079F
HEK-293T	EC₅₀	0.1 nM Compound: FTY720-P	Activity at human S1P3 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay Activity at human S1P3 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay	[PMID: 17113298]
HEK-293T	EC₅₀	1.3 nM Compound: FTY720-P	Activity at human S1P1 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay Activity at human S1P1 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay	[PMID: 17113298]
HEK-293T	EC₅₀	4 nM Compound: FTY720-P	Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay	[PMID: 17113298]
HEK-293T	EC₅₀	4 nM Compound: FTY720-P	Activity at human S1P5 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay Activity at human S1P5 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay	[PMID: 17113298]

In Vivo

(R)-FTY 720P (intravenous bolus administration ) has no clear effect on heart rate up to a dose of 0.3mg/kg in anesthetized rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 402616-23-3
분자량 387.45
화학식 C₁₉H₃₄NO₅P
SMILES

OC[C@@](CCC1=CC=C(CCCCCCCC)C=C1)(N)COP(O)(O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kiuchi M, et al. Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphate. Bioorg Med Chem. 2005 Jan 17;13(2):425-32. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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