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Cat. No.: HY-114398A

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(S)-BAY-293

Name: (S)-BAY-293
Brand: MedChemExpress
SKU: HY-114398A
Price: 360.00 USD
Availability: InStock
Rating: 5 (1 reviews)

고객리뷰

Based on 1 Customer Validation

(S)-BAY-293 is a negative control of BAY 293. BAY 293 is a potent KRAS-SOS1 interaction inhibitor.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity : 97.8%
CAS No.: 2244904-69-4
화학식: C₂₅H₂₈N₄O₂S
분자량:448.58

보관:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

(S)-BAY-293 Chemical Structure

CAS No.: 2244904-69-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

(S)-BAY-293 is a negative control of BAY 293. BAY 293 is a potent KRAS-SOS1 interaction inhibitor^[1].

All Ras Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Calu-1	IC₅₀	1840 nM Compound: Compound 24	Antiproliferative activity against human Calu-1 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay Antiproliferative activity against human Calu-1 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay	[PMID: 30683722]
K562	IC₅₀	7500 nM Compound: Compound 24	Antiproliferative activity against human K562 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay Antiproliferative activity against human K562 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay	[PMID: 30683722]
MOLM-13	IC₅₀	7570 nM Compound: Compound 24	Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay	[PMID: 30683722]
NCI-H358	IC₅₀	3390 nM Compound: Compound 24	Antiproliferative activity against human NCI-H358 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay Antiproliferative activity against human NCI-H358 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay	[PMID: 30683722]

Chemical Information

CAS No. 2244904-69-4
Appearance Solid
분자량 448.58
화학식 C₂₅H₂₈N₄O₂S
Color White to off-white
SMILES

COC1=C(OC)C=C(N=C(C)N=C2N[C@@H](C)C3=CC(C4=C(CNC)C=CC=C4)=CS3)C2=C1
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hillig RC, et, al. Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2551-2560. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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