Salviolone
Based on 1 publication(s) in Google Scholar
Salviolone is a natural diterpenoid derivative that can against melanoma cells. Salviolone exhibits a pleiotropic effect against melanoma by hampering cell cycle progression, STAT3 signaling, and malignant phenotype of A375 melanoma cells.
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- Purity: 99.32%
- CAS No.: 119400-86-1
- 화학식: C18H20O2
- 분자량:268.35
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보관:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Salviolone
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Biological Activity
제품 설명
In Vitro
Salviolone (5-60 μM; 72 hours) reduces cell viability in the A375 and MeWo melanoma cell lines with EC50 values of 17 µM and 22 µM, respectively. Salviolone does not affect the growth of normal melanocytes[1].
Salviolone (20 μM; 48-72 hours) strongly reduces pRb, pCdk2, and cyclin A2, Tyr705-STAT3 phosphorylation expression levels in A375 cells. Salviolone also strongly increases the P21 and P53 protein expression level. Salviolone induces sustained activation of the phosphorylation of ERK1/2 and Akt[1].
Salviolone (10-20 μM) inhibits MMP2 gelatinase activity in the A375 melanoma cell line[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A375, MeWo melanoma cells, and NHEM cells
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Concentration:5 μM, 10 μM, 20 μM, 30 μM, 40 μM, 50 μM, 60 μM
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Incubation Time:72 hours
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Result:Impaired the viability of melanoma cells without affecting the growth of normal melanocytes.
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Cell Line:A375 cells
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Concentration:20 μM
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Incubation Time:48 hours, 72 hours
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Result:Reduced the expression of the active forms of Cdk2 (pCdk2) and cyclin A2, and the phosphorylation of Rb.
Chemical Information
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CAS No. 119400-86-1
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Appearance Solid
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분자량 268.35
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화학식 C18H20O2
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Color Light yellow to yellow
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SMILES
O=C1C(C)=CC2=CC=C3C(C)(C)CCCC3=C2C=C1O
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Multi-Targeting Carnosic Acid Kills Drug-Resistant Helicobacter pylori With Narrow-Spectrum Activity. [Abstract]2026 Jun 11:e76080. PMID: 42272345
순도&문서
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Valentina Zanrè, et al. Salviolone from Salvia miltiorrhiza Roots Impairs Cell Cycle Progression, Colony Formation, and Metalloproteinase-2 Activity in A375 Melanoma Cells: Involvement of P21(Cip1/Waf1) Expression and STAT3 Phosphorylation. Int J Mol Sci. 2022 Jan 20;23(3):1121. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Salviolone Related Classifications
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