SC-53228
SC-53228 is an orally active human leukotriene B4 receptor (LTB4 receptor) antagonist. SC-53228 exerts its anti-inflammatory effect by specifically blocking the LTB4 receptor and inhibiting neutrophil infiltration. SC-53228 has demonstrated significant efficacy and good safety in various inflammatory models. SC-53228 can be used for a variety of inflammatory diseases, such as psoriasis and ulcerative colitis.
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- CAS No.: 153633-01-3
- 화학식: C31H41NO7
- 분자량:539.66
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All Leukotriene Receptor Isoforms
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Biological Activity
SC-53228 (100-1000 μg or 1% gel, topical administration; 2.5-10 mg/kg (mice), 40 mg/kg (monkey) p.o., single dose or once daily for 5 days) demonstrates significant anti-inflammatory effects in the psoriasis models of mice, guinea pigs, and rhesus monkeys and both local and oral administration could rapidly inhibit inflammation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Spontaneous colitis model established in Cotton-top tamarins, Saguinus Oedipus[1]
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Dosage:20 mg/kg
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Administration:Oral administration (p.o.), twice daily for 56 days
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Result:Significantly improved colitis, weight gain, and improved stool consistency.
Significantly reduced the inflammatory index, eliminate neutrophils, restore mucus production, and promote mucosal regeneration.
Chemical Information
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CAS No. 153633-01-3
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분자량 539.66
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화학식 C31H41NO7
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SMILES
CCCC1=C2C(CC[C@H](O2)CCC(O)=O)=CC=C1OCCCOC3=C(C(OC)=C(C=C3)C(NC)=O)CC4CC4
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Fretland DJ, et al. Dermal inflammation in primates, mice, and guinea pigs: attenuation by second-generation leukotriene B4 receptor antagonist, SC-53228. Inflammation. 1995 Jun;19(3):333-46. [Content Brief]
[2]. Fretland D, et al. Oral efficacy of a leukotriene B4 receptor antagonist in colitic cotton-top tamarins. Gut. 1995 Nov;37(5):702-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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