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Cat. No.: HY-10828

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SC-57461

Name: SC-57461
Brand: MedChemExpress
SKU: HY-10828
Availability: PreOrder

2 Cited Publications

고객리뷰

Based on 2 publication(s) in Google Scholar

SC-57461 is a potent, orally active, nonpeptide, and selective inhibitor of Leukotriene A4 (LTA4) hydrolase with IC₅₀s of 2.5 nM, 3 nM, and 23 nM for recombinant human, mouse, and rat LTA4 hydrolase, respectively.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 179022-08-3
화학식: C₂₀H₂₅NO₃
분자량:327.42

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

SC-57461 Chemical Structure

CAS No.: 179022-08-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
Publications (2)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

LTA4H hydrolase

2.5 (human nM (Ki)

LTA4H hydrolase

3 (mouse) nM (Ki)

LTA4H hydrolase

23 (rat) nM (Ki)

All Aminopeptidase Isoforms :

CD13
LTA4H

Chemical Information

CAS No. 179022-08-3
분자량 327.42
화학식 C₂₀H₂₅NO₃
SMILES

O=C(CCN(CCCOC1=CC=C(CC2=CC=CC=C2)C=C1)C)O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Redox Biol

Endogenous acrolein accumulation in akr7a3 mutants causes microvascular dysfunction due to increased arachidonic acid metabolism. [Abstract]

2025 Jun:83:103639. PMID: 40258306
bioRxiv

2023 Oct 23.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kachur J F, et al. Pharmacological Characterization of SC-57461A (3-[Methyl [3-[4-(phenylmethyl) phenoxy] propyl] amino] propanoic Acid HCl), a Potent and Selective Inhibitor of Leukotriene A4Hydrolase II: In Vivo Studies[J]. The Journal of pharmacology and experimental therapeutics, 2002, 300(2): 583-587.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
Publications (2)
순도&문서
References

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수량:
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SC-57461

Publications Citing Use of MedChemExpress (MCE) SC-57461

All Aminopeptidase Isoforms