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Cat. No.: HY-165532

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SGX393

Name: SGX393
Brand: MedChemExpress
SKU: HY-165532
Availability: PreOrder

(Synonyms: SGX70393)

SGX393 (SGX70393) is a Bcr-Abl kinase inhibitor. SGX393 binds to the active conformation of the kinase domains of both wild-type and T315I mutant Bcr-Abl, thereby inhibiting kinase activity. SGX393 exhibits antiproliferative effects in cells expressing wild-type or T315I mutant Bcr-Abl, and suppresses T315I-driven tumor growth. SGX393 can be used for the research of chronic myeloid leukemia.

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CAS No.: 1030610-86-6
화학식: C₂₁H₂₂N₆O
분자량:374.45

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

SGX393 Chemical Structure

CAS No.: 1030610-86-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- In Vitro
Chemical Information
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Calculators
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Biological Activity

제품 설명

All Bcr-Abl Isoforms :

Abl
Bcr-Abl

In Vitro

SGX393 potently inhibits the proliferation of Ba/F3 cells expressing WT Bcr-Abl (IC₅₀ = 12 nM) and Bcr-Abl^T315I (IC₅₀ = 7.3 nM), while being inactive against parental Ba/F3 cells^[1].
SGX393 inhibits Bcr-Abl kinase activity in primary CML cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 1030610-86-6
분자량 374.45
화학식 C₂₁H₂₂N₆O
SMILES

O=C(C=1C=C(C=CC1N)C2=CN=C3NC=C(C3=C2)C4=CC=NN4CC)N(C)C
Synonyms

SGX70393
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Schenone S, et al. New opportunities to treat the T315I-Bcr-Abl mutant in chronic myeloid leukaemia: tyrosine kinase inhibitors and molecules that act by alternative mechanisms. Curr Med Chem. 2010;17(13):1220-1245. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
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SGX393

All Bcr-Abl Isoforms

Biological Activity

제품 설명

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Bioz

Keywords

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SGX393

All Bcr-Abl Isoforms

Biological Activity

제품 설명

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

SGX393 Related Classifications

HY-165532 Related Classifications

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