Sissotrin
Based on 1 Customer Validation
Sissotrin (Biochanin A 7-glucoside; Sissonin) is an orally active isoflavone glycoside natural product found in Leguminosae plants, with weak antibacterial activity. Sissotrin exacerbates the increase in blood glucose after glucose loading. Sissotrin is used in studies related to glucose metabolism.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 98.46%
- CAS No.: 5928-26-7
- 화학식: C22H22O10
- 분자량:446.40
-
보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocol
- 순도&문서
- References
-
Help & FAQs
All Endogenous Metabolite Isoforms
More
Biological Activity
제품 설명
In Vitro
Sissotrin (compound 1) (1-1000 μM; 10 min) fails to protect HUVEC against H2O2-induced oxidative damage [1].
Sissotrin (compound 1) (500-3.906 μg/mL; 24 h) exhibits weak antibacterial activity against Shigella flexneri CPC (MIC = 250 μg/mL) and Shigella flexneri NR 518 (MIC = 500 μg/mL), but shows no activity against Staphylococcus aureus ATCC 43300, Methicillin-resistant (HY-121544) Staphylococcus aureus 33591, Escherichia coli ATCC 25922, and Staphylococcus aureus CPC[3].
Sissotrin is an isoflavone glucoside obtained via microbial glycosylation of Biochanin A (HY-14595)[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HUVEC
-
Concentration:1, 3, 10, 30, 100, 300, 1000 μM
-
Incubation Time:10 min (pre-incubation)
4 h (H2O2 challenge) -
Result:Did not prevent cellular damage induced by H2O2.
Did not show toxicity to the cells at concentrations up to 1 mM.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Wistar (Male, 140-170 g)[2]
-
Dosage:50, 100 mg/kg
-
Administration:p.o.; single administration 10 min prior to glucose load
-
Result:Caused a significant rise in blood glucose levels at 15, 30 and 60 min after the glucose load.
At 30 min after the glucose load, blood glucose was 172 mg/dL for 100 mg/kg versus 144 mg/dL for control.
Produced 133 mg/dL at 50 mg/kg.
The hyperglycaemic effect observed at 100 mg/kg was abolished at the lower dose of 50 mg/kg.
Chemical Information
-
CAS No. 5928-26-7
-
Appearance Solid
-
분자량 446.40
-
화학식 C22H22O10
-
Color White to off-white
-
SMILES
O=C1C(C2=CC=C(OC)C=C2)=COC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=CC(O)=C13
-
Synonyms
Biochanin A 7-glucoside; Sissonin
-
Structure Classification
-
Initial Source
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
순도&문서
-
Data Sheet (281 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sissotrin Related Classifications
HY-N1240 Related Classifications
Powered by Bioz
Keywords
- Sissotrin
- 5928-26-7
- Biochanin A 7-glucoside
- Sissonin
- Bacterial
- Endogenous Metabolite
- Drug Derivative
- endothelial cells
- Escherichia coli
- HUVEC
- Shighella flexineri
- Absidia glauca
- Pterospartum tridentatum
- Trifolium baccarinii
- Staphylococcus aureus
- Methicillin-resistant Staphylococcus aureus
- red clover
- Inhibitor
- inhibitor
- inhibit