SR59230A
Based on 13 publication(s) in Google Scholar
SR59230A is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively.
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- Purity: 98.0%
- CAS No.: 174689-39-5
- 화학식: C23H29NO6
- 분자량:415.48
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보관:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Publications Citing Use of MedChemExpress (MCE) SR59230A
More- Cell Metab. 2024 Jun 4;36(6):1287-1301.e7. [Abstract]
- Nat Commun. 2023 May 2;14(1):2523. [Abstract]
- Nat Commun. 2022 Jun 13;13(1):3394. [Abstract]
- J Adv Res. 2024 Dec 2:S2090-1232(24)00555-1. [Abstract]
- Cell Rep Med. 2026 Feb 17;7(2):102616. [Abstract]
- J Neuroinflammation. 2023 Dec 9;20(1):294. [Abstract]
- Eur J Pharmacol. 2022 Aug 5:928:175110. [Abstract]
- Int J Obes. 2022 Aug;46(8):1544-1555. [Abstract]
- Food Nutr Res. 2021 May 10:65. [Abstract]
- J Funct Foods. 2023 Apr.
- Biochem Biophys Res Commun. 2024 Apr 9:703:149689. [Abstract]
- Res Sq. 2025 Aug 05.
- Research Square Preprint. 2021 Dec.
Customer Validation & Images
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Histological Imaging/Staining
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WB
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IF
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In Vivo Efficacy Study
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Histological Imaging/Staining
All Adrenergic Receptor Isoforms
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Biological Activity
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β adrenergic receptor |
SR59230A (100 nM-50 μM; 24 hours) is able to reduce cell viability in a dose-dependent manner in Neuro-2A, BE(2)C and SK-N-BE(2) NB cell lines[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Three different neuroblastoma (NB) cell lines, one murine (Neuro-2A) and two human (SK-N-BE(2), BE(2)C)
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Concentration:100 nM, 1 μM, 5 μM, 10 μM, and 50 μM
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Incubation Time:24 hours
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Result:Reduced cell viability in a dose-dependent manner, with significant effect at a concentration limit over 1 µM for Neuro-2A cells and 5 µM for SK-N-BE(2) and BE(2)C).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C-57BL6J wild-type mice (22-35 g)[4]
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Dosage:0.5 or 5 mg/kg
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Administration:Injected s.c.; administered 30 min prior to the injection s.c. of MDMA (20 mg/kg).
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Result:Modulated the actions of MDMA on temperature involve α1-adrenoceptor antagonism.
Chemical Information
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CAS No. 174689-39-5
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Appearance Solid
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분자량 415.48
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화학식 C23H29NO6
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Color White to off-white
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SMILES
O[C@@H](CN[C@H]1CCCC2=C1C=CC=C2)COC3=CC=CC=C3CC.O=C(O)C(O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (13)
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Journal Impact Factor
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Most Recent
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Cell Metab
The browning and mobilization of subcutaneous white adipose tissue supports efficient skin repair. [Abstract]2024 Jun 4;36(6):1287-1301.e7. PMID: 38838641
SR59230A purchased from MedChemExpress. Usage Cited in: Cell Metab. 2024 Jun 4;36(6):1287-1301.e7. [Abstract]
H&E-stained sections and sections immunostained for UCP-1 of sWAT beneath the 7 day wound bed in C57BL/6 mice administered SR59230A (1 mg/kg; 7 d).
SR59230A purchased from MedChemExpress. Usage Cited in: Cell Metab. 2024 Jun 4;36(6):1287-1301.e7. [Abstract]
Expression of browning-related genes in the sWAT of C57BL/6 mice administered SR59230A (1 mg/kg; 7 d).
SR59230A purchased from MedChemExpress. Usage Cited in: Cell Metab. 2024 Jun 4;36(6):1287-1301.e7. [Abstract]
SR59230A (1 mg/kg; 7 d) caused greater F4/80+ macrophage infiltration into the sWAT near the wound bed of C57BL/6 mice.
SR59230A purchased from MedChemExpress. Usage Cited in: Cell Metab. 2024 Jun 4;36(6):1287-1301.e7. [Abstract]
SR59230A (1 mg/kg; 7 d) delayed wound healing of C57BL/6 mice.
SR59230A purchased from MedChemExpress. Usage Cited in: Cell Metab. 2024 Jun 4;36(6):1287-1301.e7. [Abstract]
SR59230A (1 mg/kg; 7 d) significantly suppressed the collagen deposition beyond the sWAT and delayed re-epithelialization in C57BL/6 mice.
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Nat Commun
Reduced hepatic bradykinin degradation accounts for cold-induced BAT thermogenesis and WAT browning in male mice. [Abstract]2023 May 2;14(1):2523. PMID: 37130842 -
Nat Commun
Triiodothyronine (T3) promotes brown fat hyperplasia via thyroid hormone receptor α mediated adipocyte progenitor cell proliferation. [Abstract]2022 Jun 13;13(1):3394. PMID: 35697700 -
J Adv Res
Targeting Dlat-Trpv3 pathway by hyperforin elicits non-canonical promotion of adipose thermogenesis as an effective anti-obesity strategy. [Abstract]2024 Dec 2:S2090-1232(24)00555-1. PMID: 39631519 -
Cell Rep Med
Hypothalamic malate dehydrogenase 2 modulates systemic glucose metabolism through oxytocin-mediated thermogenesis. [Abstract]2026 Feb 17;7(2):102616. PMID: 41672064 -
J Neuroinflammation
Lateralized response of skull bone marrow via osteopontin signaling in mice after ischemia reperfusion. [Abstract]2023 Dec 9;20(1):294. PMID: 38071333 -
Eur J Pharmacol
Dopamine regulates astrocytic IL-6 expression and process formation via dopamine receptors and adrenoceptors. [Abstract]2022 Aug 5:928:175110. PMID: 35738452 -
Int J Obes
TRPC5 deletion in the central amygdala antagonizes high-fat diet-induced obesity by increasing sympathetic innervation. [Abstract]2022 Aug;46(8):1544-1555. PMID: 35589963 -
Food Nutr Res
Sesamol promotes browning of white adipocytes to ameliorate obesity by inducing mitochondrial biogenesis and inhibition mitophagy via β3-AR/PKA signaling pathway. [Abstract]2021 May 10:65. PMID: 34262421 -
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Biochem Biophys Res Commun
Olodaterol promotes thermogenesis in brown adipocytes via regulation of the β2-AR/cAMP/PKA signaling pathway. [Abstract]2024 Apr 9:703:149689. PMID: 38382361 -
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용액&용해도
DMSO : 125 mg/mL (300.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (5.01 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (5.01 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Nisoli E, et al. Functional studies of the first selective beta 3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes.Mol Pharmacol. 1996 Jan;49(1):7-14. [Content Brief]
[2]. Kanzler SA, et al. Involvement of β3-adrenergic receptors in the control of food intake in rats.Braz J Med Biol Res. 2011 Nov;44(11):1141-7. [Content Brief]
[3]. Bruno G, et al. β3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P2 modulation.Oncogene. 2020 Jan;39(2):368-384. [Content Brief]
[4]. Bexis S, et al. Role of alpha 1- and beta 3-adrenoceptors in the modulation by SR59230A of the effects of MDMA on body temperature in the mouse. Br J Pharmacol. 2009 Sep;158(1):259-66. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4069 mL | 12.0343 mL | 24.0685 mL | 60.1714 mL |
| 5 mM | 0.4814 mL | 2.4069 mL | 4.8137 mL | 12.0343 mL | |
| 10 mM | 0.2407 mL | 1.2034 mL | 2.4069 mL | 6.0171 mL | |
| 15 mM | 0.1605 mL | 0.8023 mL | 1.6046 mL | 4.0114 mL | |
| 20 mM | 0.1203 mL | 0.6017 mL | 1.2034 mL | 3.0086 mL | |
| 25 mM | 0.0963 mL | 0.4814 mL | 0.9627 mL | 2.4069 mL | |
| 30 mM | 0.0802 mL | 0.4011 mL | 0.8023 mL | 2.0057 mL | |
| 40 mM | 0.0602 mL | 0.3009 mL | 0.6017 mL | 1.5043 mL | |
| 50 mM | 0.0481 mL | 0.2407 mL | 0.4814 mL | 1.2034 mL | |
| 60 mM | 0.0401 mL | 0.2006 mL | 0.4011 mL | 1.0029 mL | |
| 80 mM | 0.0301 mL | 0.1504 mL | 0.3009 mL | 0.7521 mL | |
| 100 mM | 0.0241 mL | 0.1203 mL | 0.2407 mL | 0.6017 mL |
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