Cat. No.: HY-133222

STX140

Name: STX140
Brand: MedChemExpress
SKU: HY-133222
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STX140 is an orally active microtubule disruptor. STX140 induces apoptosis in the hormone-independent PC-3 prostate cell lines. STX140 has anti-angiogenic and anti-tumour activities.

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CAS No.: 401600-86-0
화학식: C₁₉H₂₈N₂O₇S₂
분자량:460.56

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

STX140 Chemical Structure

CAS No.: 401600-86-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

STX140 is an orally active microtubule disruptor. STX140 induces apoptosis in the hormone-independent PC-3 prostate cell lines. STX140 has anti-angiogenic and anti-tumour activities^[1].

All Estrogen Receptor/ERR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	GI₅₀	0.083 μM Compound: 21, 2-MeOE2bisMATE	Growth inhibition of human DU145 cell line Growth inhibition of human DU145 cell line	[PMID: 17181151]
DU-145	GI₅₀	0.34 μM Compound: 2	Antiproliferative activity against human DU145 cells after 96 hrs by WST-1 assay Antiproliferative activity against human DU145 cells after 96 hrs by WST-1 assay	[PMID: 20225862]
DU-145	GI₅₀	0.34 μM Compound: 3	Antiproliferative activity against human DU145 cells after 96 hrs by WST1 assay Antiproliferative activity against human DU145 cells after 96 hrs by WST1 assay	[PMID: 17696419]
DU-145	GI₅₀	0.34 μM Compound: 3, 2-MeO2bisMATE	Antiproliferative activity against human DU145 cells Antiproliferative activity against human DU145 cells	[PMID: 18260615]
HCT-116	GI₅₀	0.045 μM Compound: 2	Antiproliferative activity against human HCT116 cells after 96 hrs by WST-1 assay Antiproliferative activity against human HCT116 cells after 96 hrs by WST-1 assay	[PMID: 20225862]
HCT-116	GI₅₀	0.045 μM Compound: 21, 2-MeOE2bisMATE	Growth inhibition of human HCT116 cell line Growth inhibition of human HCT116 cell line	[PMID: 17181151]
HCT-116	GI₅₀	0.045 μM Compound: 3, 2-MeO2bisMATE	Antiproliferative activity against human HCT116 cells Antiproliferative activity against human HCT116 cells	[PMID: 18260615]
HOP-62	GI₅₀	0.051 μM Compound: 2	Antiproliferative activity against human HOP62 cells after 96 hrs by WST-1 assay Antiproliferative activity against human HOP62 cells after 96 hrs by WST-1 assay	[PMID: 20225862]
HOP-62	GI₅₀	0.051 μM Compound: 21, 2-MeOE2bisMATE	Growth inhibition of human HOP62 cell line Growth inhibition of human HOP62 cell line	[PMID: 17181151]
HOP-62	GI₅₀	0.051 μM Compound: 3, 2-MeO2bisMATE	Antiproliferative activity against human HOP62 cells Antiproliferative activity against human HOP62 cells	[PMID: 18260615]
HUVEC	IC₅₀	0.13 μM Compound: 21, 2-MeOE2bisMATE	Antiangiogenic activity assessed as inhibition of cord formation in HUVEC Antiangiogenic activity assessed as inhibition of cord formation in HUVEC	[PMID: 17181151]
HUVEC	IC₅₀	0.4 μM Compound: 21, 2-MeOE2bisMATE	Antiangiogenic activity in HUVEC by chemotaxis assay Antiangiogenic activity in HUVEC by chemotaxis assay	[PMID: 17181151]
HUVEC	IC₅₀	0.7 μM Compound: 21, 2-MeOE2bisMATE	Antiangiogenic activity assessed as growth inhibition in HUVEC Antiangiogenic activity assessed as growth inhibition in HUVEC	[PMID: 17181151]
HUVEC	IC₅₀	44 nM Compound: 3, 2-MeO2bisMATE	Antiangiogenic activity against HUVEC cells assessed as inhibition of proliferation Antiangiogenic activity against HUVEC cells assessed as inhibition of proliferation	[PMID: 18260615]
MCF7	GI₅₀	0.25 μM Compound: 21, 2-MeOE2bisMATE	Antiproliferative activity against human MCF7 cell line Antiproliferative activity against human MCF7 cell line	[PMID: 17181151]
MCF7	GI₅₀	0.25 μM Compound: 3, 2-MeO2bisMATE	Antiproliferative activity against estrogen receptor positive human MCF7 cells Antiproliferative activity against estrogen receptor positive human MCF7 cells	[PMID: 18260615]
MCF7	IC₅₀	0.25 μM Compound: 15	Antiproliferative activity against estrogen receptor-positive human MCF7 cells Antiproliferative activity against estrogen receptor-positive human MCF7 cells	[PMID: 31255926]
MDA-MB-231	ED₅₀	10 mg/kg Compound: 43	Antitumor activity against human MDA-MB-231 cells xenografted in MF1 mouse administered daily Antitumor activity against human MDA-MB-231 cells xenografted in MF1 mouse administered daily	[PMID: 25992880]
MDA-MB-231	ED₅₀	20 mg/kg Compound: 43	Antitumor activity against human MDA-MB-231 cells xenografted in MF1 mouse administered thrice weekly Antitumor activity against human MDA-MB-231 cells xenografted in MF1 mouse administered thrice weekly	[PMID: 25992880]
MDA-MB-231	GI₅₀	0.28 μM Compound: 2	Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by WST-1 assay Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by WST-1 assay	[PMID: 20225862]
MDA-MB-231	GI₅₀	0.28 μM Compound: 3	Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by WST1 assay Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by WST1 assay	[PMID: 17696419]
MDA-MB-231	GI₅₀	0.28 μM Compound: 3, 2-MeO2bisMATE	Antiproliferative activity against estrogen receptor negative human MDA-MB-231 cells Antiproliferative activity against estrogen receptor negative human MDA-MB-231 cells	[PMID: 18260615]
MDA-MB-231	IC₅₀	0.29 μM Compound: 15	Antiproliferative activity against estrogen receptor-negative human MDA-MB-231 cells Antiproliferative activity against estrogen receptor-negative human MDA-MB-231 cells	[PMID: 31255926]
MDA-MB-435	GI₅₀	<0.01 μM Compound: 21, 2-MeOE2bisMATE	Growth inhibition of human MDA-MB-435 cell line Growth inhibition of human MDA-MB-435 cell line	[PMID: 17181151]
MDA-MB-435	GI₅₀	<0.01 μM Compound: 3, 2-MeO2bisMATE	Antiproliferative activity against human MDA-MB-435 cells Antiproliferative activity against human MDA-MB-435 cells	[PMID: 18260615]
OVCAR-3	GI₅₀	<0.01 μM Compound: 2	Antiproliferative activity against human OVCAR-3 cells after 96 hrs by WST-1 assay Antiproliferative activity against human OVCAR-3 cells after 96 hrs by WST-1 assay	[PMID: 20225862]
OVCAR-3	GI₅₀	<0.01 μM Compound: 21, 2-MeOE2bisMATE	Growth inhibition of human OVCAR-3 cell line Growth inhibition of human OVCAR-3 cell line	[PMID: 17181151]
OVCAR-3	GI₅₀	<0.01 μM Compound: 3, 2-MeO2bisMATE	Antiproliferative activity against human OVCAR-3 cells Antiproliferative activity against human OVCAR-3 cells	[PMID: 18260615]
SF-539	GI₅₀	0.036 μM Compound: 2	Antiproliferative activity against human SF539 cells after 96 hrs by WST-1 assay Antiproliferative activity against human SF539 cells after 96 hrs by WST-1 assay	[PMID: 20225862]
SF-539	GI₅₀	0.036 μM Compound: 21, 2-MeOE2bisMATE	Growth inhibition of human SF539 cell line Growth inhibition of human SF539 cell line	[PMID: 17181151]
SF-539	GI₅₀	0.036 μM Compound: 3, 2-MeO2bisMATE	Antiproliferative activity against human SF539 cells at Antiproliferative activity against human SF539 cells at	[PMID: 18260615]
SN12C	GI₅₀	0.126 μM Compound: 2	Antiproliferative activity against human SN12C cells after 96 hrs by WST-1 assay Antiproliferative activity against human SN12C cells after 96 hrs by WST-1 assay	[PMID: 20225862]
SN12C	GI₅₀	0.126 μM Compound: 21, 2-MeOE2bisMATE	Growth inhibition of human SN12-C cell line Growth inhibition of human SN12-C cell line	[PMID: 17181151]
SN12C	GI₅₀	0.126 μM Compound: 3, 2-MeO2bisMATE	Antiproliferative activity against human SN12-C cells Antiproliferative activity against human SN12-C cells	[PMID: 18260615]
UACC-62	GI₅₀	<0.01 μM Compound: 2	Antiproliferative activity against human UACC62 cells after 96 hrs by WST-1 assay Antiproliferative activity against human UACC62 cells after 96 hrs by WST-1 assay	[PMID: 20225862]
UACC-62	GI₅₀	<0.01 μM Compound: 21, 2-MeOE2bisMATE	Growth inhibition of human UACC62 cell line Growth inhibition of human UACC62 cell line	[PMID: 17181151]
UACC-62	GI₅₀	<0.01 μM Compound: 3, 2-MeO2bisMATE	Antiproliferative activity against human UACC62 cells Antiproliferative activity against human UACC62 cells	[PMID: 18260615]

In Vitro

STX140 is a potent inhibitor of cell proliferation in a panel of prostate and breast cancer cell lines, with IC₅₀ values of 270 nM, 290 nM, 260 nM, 250 nM, 280 nM, and 44 nM for PC-3, MDA-MB-231, LNCaP, MCF-7, A2780, and HUVEC, respectively^[1].
STX140 (0.5 μM; 24 h) potently induces cell cycle arrest. STX140 induces apoptosis in the hormone-independent PC-3 prostate cell line^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

PC-3 cells
Concentration:

0.5 μM
Incubation Time:

24 h
Result:

Potently induced cell cycle arrest with 71% of PC-3 cells being in G2/M after 24 h and 6% in G1.

In Vivo

STX140 (20 mg/kg; p.o.; once daily; 60 days) leads to tumour regression and complete responses, which are maintained after the cessation of dosing^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male MF-1 nu/nu mice injected with PC-3 cells^[1]
Dosage:

20 mg/kg
Administration:

p.o.; once daily; 60 days
Result:

Led to tumour regression and complete responses.

Chemical Information

CAS No. 401600-86-0
분자량 460.56
화학식 C₁₉H₂₈N₂O₇S₂
SMILES

C[C@@]12[C@](CC[C@@H]2OS(N)(=O)=O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC(OC)=C(OS(N)(=O)=O)C=C4CC3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. S P Newman, et al. The therapeutic potential of a series of orally bioavailable anti-angiogenic microtubule disruptors as therapy for hormone-independent prostate and breast cancers. Br J Cancer. 2007 Dec 17;97(12):1673-82. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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STX140

All Estrogen Receptor/ERR Isoforms