country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-N12104

Copy Link Print Information

Trichodimerol

(Synonyms: BMS-182123)

Trichodimerol (BMS-182123) is a TNF-α promoter inhibitor that inhibits the activity of lipopolysaccharide-induced cytokine secretion. Trichodimerol inhibits lipopolysaccharide-induced TNF-α promoter activity, reduces steady-state TNF-α mRNA expression, and does not alter the stability of TNF-α mRNA. Trichodimerol inhibits lipopolysaccharide-induced TNF-α secretion in murine and human immune cells. Trichodimerol reduces lipopolysaccharide-induced IL-1β secretion by 25%-50% in vitro. Trichodimerol does not alter total protein synthesis or constitutive lysozyme secretion at effective concentrations. Trichodimerol can be used for the research of septic shock.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 145174-90-9
화학식: C₂₈H₃₂O₈
분자량:496.55

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Trichodimerol Chemical Structure

CAS No.: 145174-90-9

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All TNF Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Jurkat	IC₅₀	28.5 μM Compound: 16	Cytotoxicity against human Jurkat cells after 24 hrs by MTT assay Cytotoxicity against human Jurkat cells after 24 hrs by MTT assay	[PMID: 21146414]
K562	IC₅₀	47.8 μM Compound: 16	Inhibition of NF-kappaB activity in TNFalpha-stimulated human K562 cells after 24 hrs by luciferase reporter gene assay Inhibition of NF-kappaB activity in TNFalpha-stimulated human K562 cells after 24 hrs by luciferase reporter gene assay	[PMID: 21146414]
K562	IC₅₀	74.4 μM Compound: 16	Cytotoxicity against human K562 cells after 24 hrs by MTT assay Cytotoxicity against human K562 cells after 24 hrs by MTT assay	[PMID: 21146414]
U-937	IC₅₀	16.5 μM Compound: 16	Cytotoxicity against human U937 cells after 24 hrs by MTT assay Cytotoxicity against human U937 cells after 24 hrs by MTT assay	[PMID: 21146414]

In Vitro

Trichodimerol (BMS-182123) (concentrations leading to >99% inhibition; ~20 h) concentration-dependently inhibits LPS-induced TNF-α production in murine RAW 264.7 macrophages with an IC₅₀ of 600 ng/mL^[1].
Trichodimerol (BMS-182123) (0.1-4.0 μg/mL; 2 h) concentration-dependently inhibits LPS-induced TNF-α production in human peripheral blood monocytes with an IC₅₀ of 4.0 μg/mL^[1].
Trichodimerol (BMS-182123) (concentrations leading to full inhibition; 18-20 h) concentration-dependently inhibits LPS-induced human TNF-α promoter activity in transfected murine RAW macrophages with an IC₅₀ of 200 ng/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

Murine macrophages
Concentration:

2 μg/mL
Incubation Time:

4 h
Result:

Significantly reduced LPS-induced steady-state TNF-α mRNA expression in murine macrophages without altering mRNA stability.

Chemical Information

CAS No. 145174-90-9
분자량 496.55
화학식 C₂₈H₃₂O₈
SMILES

C[C@@]12[C@@]3([H])[C@]4([C@@](O1)([C@]5(O[C@@]2([C@@](C(O)=C3C(/C=C/C=C/C)=O)([C@@]5([H])C(C(/C=C/C=C/C)=O)=C4O)C)O)C)O)C
Synonyms

BMS-182123
Structure Classification
- Others
Initial Source
- Endogenous metabolite
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Warr GA, et al. BMS-182123, a fungal metabolite that inhibits the production of TNF-alpha by macrophages and monocytes. J Antibiot (Tokyo). 1996;49(3):234-240. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

Trichodimerol

All TNF Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Trichodimerol Related Classifications

HY-N12104 Related Classifications